Preclinical Pharmacodynamics of Central Nervous System Active Agents

  • M. Danhof
  • J. W. Mandema
  • A. Hoogerkamp


In preclinical drug development power spectral analysis of drug induced changes in the electroencephalogram (EEG) is often used to characterize the pharmacological properties of new psychotropic drugs. In this chapter a new approach is proposed for this type of investigations, which allows additional quantitative pharmacodynamic information (i.e. potency, intrinsic efficacy, rate of biophase equilibration) to be derived.


Psychotropic Drug Small Laboratory Animal Unit Impulse Response Intrinsic Efficacy Sigmoidal Emax Model 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • M. Danhof
    • 1
  • J. W. Mandema
    • 1
  • A. Hoogerkamp
    • 1
  1. 1.Center for Bio-Pharmaceutical Sciences Division of PharmacologyUniversity of Leiden, Sylvius LaboratoryLeidenThe Netherlands

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