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Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development pp 69–80Cite as

Preclinical Pharmacodynamics of Central Nervous System Active Agents

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Abstract

In preclinical drug development power spectral analysis of drug induced changes in the electroencephalogram (EEG) is often used to characterize the pharmacological properties of new psychotropic drugs. In this chapter a new approach is proposed for this type of investigations, which allows additional quantitative pharmacodynamic information (i.e. potency, intrinsic efficacy, rate of biophase equilibration) to be derived.

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Authors and Affiliations

  1. Center for Bio-Pharmaceutical Sciences Division of Pharmacology, University of Leiden, Sylvius Laboratory, P.O. Box 9503, 2300 RA, Leiden, The Netherlands

    M. Danhof, J. W. Mandema & A. Hoogerkamp

Authors
  1. M. Danhof
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  2. J. W. Mandema
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  3. A. Hoogerkamp
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Editor information

Editors and Affiliations

  1. Pharmacodynamics Research, American Cyanamid Company, Medical Research, Pearl River, New York, USA

    Avraham Yacobi Ph.D. (Director) (Director)

  2. Office of Research Resources, Center for Drug Evaluation and Research, Food and Drug Administration, Washington, D.C., USA

    Jerome P. Skelly Ph.D. (Deputy Director) (Deputy Director)

  3. Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA

    Vinod P. Shah Ph.D. (Acting Deputy Associate Director for Science) (Acting Deputy Associate Director for Science)

  4. Department of Pharmacy, School of Pharmacy, University of California, San Francisco, San Francisco, California, USA

    Leslie Z. Benet Ph.D., Pharm.D.(Hon.) (Professor and Chairman) (Professor and Chairman)

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© 1993 Springer Science+Business Media New York

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Danhof, M., Mandema, J.W., Hoogerkamp, A. (1993). Preclinical Pharmacodynamics of Central Nervous System Active Agents. In: Yacobi, A., Skelly, J.P., Shah, V.P., Benet, L.Z. (eds) Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1520-0_9

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  • DOI: https://doi.org/10.1007/978-1-4757-1520-0_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1522-4

  • Online ISBN: 978-1-4757-1520-0

  • eBook Packages: Springer Book Archive

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