Use of Acute Toxicity Data in the Design and Interpretation of Subchronic and Chronic Toxicity Studies

  • Karl K. Rozman


This contribution shows that the relative toxic potency of 4 chlorinated dibenzo-pdioxins (CDDs) is similar in 2 species with different sensitivities (guinea pig, rat). More importantly, it also demonstrates that the relative toxic potencies of these homologues and their mixture is essentially identical for acute, subchronic and chronic dosing in the same species (rat). The importance and usefulness of careful considerations of toxicokinetic and toxicodynamic data obtained in acute experiments for the design of subchronic and chronic toxicity studies is discussed.


Dose Response Dose Response Curve Maximum Tolerate Dose Relative Potency Chronic Toxicity 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Karl K. Rozman
    • 1
    • 2
  1. 1.Department of Pharmacology, Toxicology & TherapeuticsUniversity of Kansas Medical CenterKansas CityUSA
  2. 2.Section of Environmental ToxicologyGSF-Institut für ToxikologieNeuherbergGermany

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