Abstract
This contribution shows that the relative toxic potency of 4 chlorinated dibenzo-pdioxins (CDDs) is similar in 2 species with different sensitivities (guinea pig, rat). More importantly, it also demonstrates that the relative toxic potencies of these homologues and their mixture is essentially identical for acute, subchronic and chronic dosing in the same species (rat). The importance and usefulness of careful considerations of toxicokinetic and toxicodynamic data obtained in acute experiments for the design of subchronic and chronic toxicity studies is discussed.
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Rozman, K.K. (1993). Use of Acute Toxicity Data in the Design and Interpretation of Subchronic and Chronic Toxicity Studies. In: Yacobi, A., Skelly, J.P., Shah, V.P., Benet, L.Z. (eds) Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1520-0_6
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DOI: https://doi.org/10.1007/978-1-4757-1520-0_6
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