The Integration of Pharmacodynamics and Pharmacokinetics in Rational Drug Development

  • Sally Usdin Yasuda
  • Sorell L. Schwartz
  • Anton Wellstein
  • Raymond L. Woosley

Abstract

Pharmacokinetic and pharmacodynamic analyses have been found to be valuable components of new drug development programs. This chapter will describe developments in pharmacokinetic and pharmacodynamic studies that have taken place in recent years. An understanding of the relationship between pharmacokinetics and pharmacodynamics and the integration of each type of study will allow even greater contributions to drug development and pharmacological research.

Keywords

Receptor Occupancy PBPK Model Extensive Metabolizers Effect Compartment Radioreceptor Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Sally Usdin Yasuda
    • 1
  • Sorell L. Schwartz
    • 1
  • Anton Wellstein
    • 1
  • Raymond L. Woosley
    • 1
  1. 1.The Department of PharmacologyGeorgetown University Medical CenterUSA

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