The Role of Pharmacokinetics in the Drug Development Process
Ten critical pharmacokinetic and pharmacodynamic parameters should be determined for each new drug, both in test animal species and in man. These ten parameters, listed in order of importance, are: 1) clearance, 2) effective concentrations, 3) extent of availability, 4) fraction of the available dose excreted unchanged, 5) the blood/plasma concentration ratio, 6) half-life, 7) toxic concentrations, 8) protein binding, 9) volume of distribution, and 10) rate of availability.
KeywordsHepatic Blood Flow Extraction Ratio Oral Dosage Form Drug Development Process Plasma Concentration Ratio
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