Ten critical pharmacokinetic and pharmacodynamic parameters should be determined for each new drug, both in test animal species and in man. These ten parameters, listed in order of importance, are: 1) clearance, 2) effective concentrations, 3) extent of availability, 4) fraction of the available dose excreted unchanged, 5) the blood/plasma concentration ratio, 6) half-life, 7) toxic concentrations, 8) protein binding, 9) volume of distribution, and 10) rate of availability.


Hepatic Blood Flow Extraction Ratio Oral Dosage Form Drug Development Process Plasma Concentration Ratio 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Leslie Z. Benet
    • 1
  1. 1.Department of PharmacyUniversity of CaliforniaSan FranciscoUSA

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