Transport of Materials through the Walls of Different Blood Vessels

  • M. John Lever
  • Mark T. Jay
Part of the NATO ASI Series book series (NSSA, volume 193)


The blood vessels exhibit wide variations in structure from one site in the body to another. The marked differences in the composition, the ultrastructural organization of tissue components and the thickness of the vessel walls presumably reflect differences in the mechanical forces and chemical environment which prevailed during their growth. As the vessels age, differences also appear in their susceptibility to atherosclerosis. Veins are normally spared from the disease, except when they take on the features of arteries following the develoment of an arterio-venous fistula, or when they are used as arterial grafts. The pulmonary arteries also tend to be affected by atherosclerosis only if there is pulmonary hypertension. Even amongst the systemic arteries there is marked variability in susceptibility; vessels smaller than 1mm are rarely affected and the ascending portion of the aorta is normally affected to a lesser extent than the abdominal region.


Pulmonary Artery Inferior Vena Luminal Surface Transmural Pressure Systemic Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Christensen S., Stender S., Nyvad O. and Bagger H., 1982, In vivo fluxes of plasma cholesterol, phosphatidylcholine and protein into mini-pig aortic and pulmonary segments. Atherosclerosis 41: 309–319.Google Scholar
  2. Duncan L.E., Buck K. and Lynch A., 1963, Lipoprotein movement through canine aortic wall. Science 142: 972–973.Google Scholar
  3. Lin S.J., Jan K.M., Schuessler G., Weinbaum S. and Chien S., 1988, Enhanced macromolecular permeability of aortic endothelial cells in association with mitosis. Atherosclerosis 73: 223–232.Google Scholar
  4. Nerem R.M., Levesque M. and Cornhill J.F.,1981,Vascular endothelial morphology as an indicator of blood flow. ASME J. Biomech. Eng. 103:172.CrossRefGoogle Scholar
  5. Packham M.A., Rowsell H.C., Jorgensen L. and Mustard J.F., 1967, Localized protein accumulation in the wall of the aorta. Exp. Mol. Pathol. 7:214–232.PubMedCrossRefGoogle Scholar
  6. Schwartz S.A. and Benditt E.P., 1973, Cell replication in the aortic endothelium: a new method for study of the problem. Lab. Invest. 28:699–707.PubMedGoogle Scholar
  7. Somer J.B. and Schwartz C.J., 1971, Focal 3H-cholesterol uptake in the pig aorta. Atherosclerosis 13: 293–304.Google Scholar
  8. Stemerman M.B., Morrel E.M., Burke K.R., Colton C.K., Smith K.A. and Lees R.S., 1986, Local variation in arterial wall permeability to low density lipoprotein in normal rabbit aorta. Arteriosclerosis,6:64–69.Google Scholar
  9. Tedgui A. and Lever M.J., 1987, Effect of pressure and intimal damage on the 131-I albumin and 14C-sucrose spaces in aorta. Am. J. Physiol. 253:H1530–1539.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • M. John Lever
    • 1
  • Mark T. Jay
    • 1
  1. 1.Physiological Flow Studies UnitImperial College of Science, Technology and MedicineLondonUK

Personalised recommendations