Abstract
The endothelial lining of arteries is anatomically well sited to convey physiological information about local blood flow to underlying smooth muscle cells, and by releasing endothelium-derived relaxing factor (EDRF) in response to shear stress (Pohl et al., 1986; Rubanyi et al., 1986) mediates flow-dependent dilatation of both conduit (Holtz et al., 1983; Melkumyants et al., 1989) and resistance arteries (Griffith et al., 1987; Griffith and Edwards, 1990). Flow-dependent dilatation provides a way of coordinating responses in different parts of the arterial tree: a metabolically-induced reduction in distal resistance, for example, can produce a secondary fall in the resistance of more proximal “feed vessels” simply as a consequence of the accompanying increase in flow (Holtz et al., 1983).
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Griffith, T.M., Edwards, D.H. (1990). Regulation of Flow in Vascular Networks by EDRF. In: Mosora, F., Caro, C.G., Krause, E., Schmid-Schönbein, H., Baquey, C., Pelissier, R. (eds) Biomechanical Transport Processes. NATO ASI Series, vol 193. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1511-8_18
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DOI: https://doi.org/10.1007/978-1-4757-1511-8_18
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