Regulation of Flow in Vascular Networks by EDRF

  • T M Griffith
  • D H Edwards
Part of the NATO ASI Series book series (NSSA, volume 193)


The endothelial lining of arteries is anatomically well sited to convey physiological information about local blood flow to underlying smooth muscle cells, and by releasing endothelium-derived relaxing factor (EDRF) in response to shear stress (Pohl et al., 1986; Rubanyi et al., 1986) mediates flow-dependent dilatation of both conduit (Holtz et al., 1983; Melkumyants et al., 1989) and resistance arteries (Griffith et al., 1987; Griffith and Edwards, 1990). Flow-dependent dilatation provides a way of coordinating responses in different parts of the arterial tree: a metabolically-induced reduction in distal resistance, for example, can produce a secondary fall in the resistance of more proximal “feed vessels” simply as a consequence of the accompanying increase in flow (Holtz et al., 1983).


Resistance Artery Geometrical Similarity Asymmetry Ratio Constrictor Response Minimum Power Loss 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • T M Griffith
    • 1
  • D H Edwards
    • 2
  1. 1.Departments of Diagnostic RadiologyUniversity of Wales College of MedicineCardiffUK
  2. 2.Departments of CardiologyUniversity of Wales College of MedicineCardiffUK

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