Calcitonin: Molecular Biology, Physiology, Pathophysiology and Its Therapeutic Uses

  • Sunil J. Wimalawansa
Part of the NATO ASI Series book series (NSSA, volume 184)

Abstract

Calcitonin (CT) is a 32 amino acid peptide hormone, and its existence was postulated in 1962 by Copp and colleagues (Copp et al, 1962) (for review see Queener & Bell, 1975; Maclntyre et al, 1988; Wimalawansa & Maclntyre, 1989b). Initial studies on sheep suggested the parathyroid gland as the source of CT (Copp & Henze, 1964). Later, the source of this calcium lowering factor was identified as the thyroid gland (Foster et al, 1964a). CT is synthesised by the parafollicular cells (C-cells) of the thyroid in mammals (Foster et al, 1964b; Pearse, 1966; Bussolati and Pearse, 1967); and by C-cells associated with the ultimobranchial gland in lower vertebrates (Copp et al, 1967; Tauber, 1967). The C-cells derive from the neural crest (Le Dourain and Le Leivre, 1970) and migrate forward to become the ultimobranchial body in lower vertebrates and the parafollicular cells in man (Pearse & Polak, 1971) and related species (Pearse and Carvalheira, 1967).

Keywords

Medullary Thyroid Carcinoma Salmon Calcitonin Calcitonin Receptor Human Calcitonin Medullary Thyroid Carcinoma Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Sunil J. Wimalawansa
    • 1
  1. 1.Endocrine Unit, Dept. Chemical PathologyRoyal Postgraduate Medical SchoolLondonUK

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