Role of Parathyroid Hormone in Bone Formation and Resorption

  • Roger Smith
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 184)


One of the most striking effects of parathyroid hormone (PTH) is that on bone. Osteitis fibrosa cystica was early recognised as a characteristic feature of bone in patients with hyperparathyroidism (Hunter and Turnbull, 1932). The main pathological changes which lead to this include an increase in number (and apparently activity) of osteoclasts, marrow fibrosis, and sometimes the formation of expanded cyst-like lesions, or brown tumours. Although excess bone resorption predominates, and is well documented radiologically at particular sites, such as the phalanges and ends of the long bones, there is often an increase in bone formation. This is exemplified by the osteosclerosis of secondary hyperparathyroidism in renal glomerular osteodystrophy.


Bone Resorption Primary Hyperparathyroidism Secondary Hyperparathyroidism Osteoclastic Bone Resorption Osteitis Fibrosa 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Roger Smith
    • 1
  1. 1.Nuffield Orthopaedic Centre and John Radcliffe HospitalHeadington OxfordUK

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