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Role of Parathyroid Hormone in Bone Formation and Resorption

  • Conference paper
Book cover Bone Regulatory Factors

Part of the book series: NATO ASI Series ((NSSA,volume 184))

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Abstract

One of the most striking effects of parathyroid hormone (PTH) is that on bone. Osteitis fibrosa cystica was early recognised as a characteristic feature of bone in patients with hyperparathyroidism (Hunter and Turnbull, 1932). The main pathological changes which lead to this include an increase in number (and apparently activity) of osteoclasts, marrow fibrosis, and sometimes the formation of expanded cyst-like lesions, or brown tumours. Although excess bone resorption predominates, and is well documented radiologically at particular sites, such as the phalanges and ends of the long bones, there is often an increase in bone formation. This is exemplified by the osteosclerosis of secondary hyperparathyroidism in renal glomerular osteodystrophy.

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Author information

Authors and Affiliations

  1. Nuffield Orthopaedic Centre and John Radcliffe Hospital, Headington Oxford, UK

    Roger Smith

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  1. Roger Smith
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Editor information

Editors and Affiliations

  1. University of Milan, Milan, Italy

    Antonio Pecile (Professor of Pharmacology) (Professor of Pharmacology)

  2. Biophysics and Chemistry of Macromolecules, University of Trieste, Trieste, Italy

    Benedetto de Bernard (Head of the Dept. of Biochemistry) (Head of the Dept. of Biochemistry)

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© 1990 Springer Science+Business Media New York

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Smith, R. (1990). Role of Parathyroid Hormone in Bone Formation and Resorption. In: Pecile, A., de Bernard, B. (eds) Bone Regulatory Factors. NATO ASI Series, vol 184. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1508-8_8

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  • DOI: https://doi.org/10.1007/978-1-4757-1508-8_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1510-1

  • Online ISBN: 978-1-4757-1508-8

  • eBook Packages: Springer Book Archive

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