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The Role of Cells in the Calcification Process

  • Conference paper
Book cover Bone Regulatory Factors

Part of the book series: NATO ASI Series ((NSSA,volume 184))

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Abstract

Although the vertebrate body contains an abundance of potential sites for mineralization, not every tissue calcifies, which indicates that regulatory processes are operative. The mechanisms responsible for stimulating and inhibiting the initiation and progression of mineralization are likely to be cell-mediated, and various experimental systems have been used to study the involvement of cells, the function of which may be regulated systemically or locally. In this chapter, we will discuss experiments in which we studied the role of vitamin D metabolites as regulators of bone matrix calcification in rats in vivo and experiments designed to analyse the factors involved in regulation of de novo mineralization of bone formed in vitro. First, however, we present a brief overview of the matrix constituents associated with calcification.

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Author information

Authors and Affiliations

  1. MRC Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

    J. N. M. Heersche, C. G. Bellows & J. E. Aubin

  2. Mt. Sinai Hospital Research Institute and Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

    H. C. Tenenbaum

  3. Queen Elizabeth Hospital Research Institute and Dept. of Pathology, University of Toronto, Toronto, Ontario, Canada

    C. S. Tam

Authors
  1. J. N. M. Heersche
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  2. H. C. Tenenbaum
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  3. C. S. Tam
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  4. C. G. Bellows
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  5. J. E. Aubin
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Editor information

Editors and Affiliations

  1. University of Milan, Milan, Italy

    Antonio Pecile (Professor of Pharmacology) (Professor of Pharmacology)

  2. Biophysics and Chemistry of Macromolecules, University of Trieste, Trieste, Italy

    Benedetto de Bernard (Head of the Dept. of Biochemistry) (Head of the Dept. of Biochemistry)

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© 1990 Springer Science+Business Media New York

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Heersche, J.N.M., Tenenbaum, H.C., Tam, C.S., Bellows, C.G., Aubin, J.E. (1990). The Role of Cells in the Calcification Process. In: Pecile, A., de Bernard, B. (eds) Bone Regulatory Factors. NATO ASI Series, vol 184. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1508-8_5

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  • DOI: https://doi.org/10.1007/978-1-4757-1508-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1510-1

  • Online ISBN: 978-1-4757-1508-8

  • eBook Packages: Springer Book Archive

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