Melatonin Secretion — A Biological Marker for Human Pineal Adrenergic Function

  • Alfred J. Lewy
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 65)


Spanning the last 20 years, hundreds of anatomical and pharmacological studies have indicated that melatonin secretion by the mammalian pineal gland is an ideal “biological marker” for adrenergic function, the endogenous circadian pacemaker, and the effects of light. Nighttime beta-adrenergic stimulation of melatonin synthesis provides the theoretical basis for using the pineal as a model of adrenergic function. The biochemical steps resulting in melatonin synthesis appear to be intricately coordinated.


Multiple System Atrophy Pineal Gland Melatonin Level Melatonin Secretion Melatonin Production 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Alfred J. Lewy
    • 1
  1. 1.Departments of Psychiatry, Pharmacology and Ophthalmology Oregon Health SciencesUniversity PortlandUSA

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