Skip to main content

Pineal-Hypothalamic Interactions: Possible Role of the Monoaminergic Neuron System

  • Chapter
The Pineal Gland and its Endocrine Role

Part of the book series: NATO Advanced Science Institutes Series ((NSSA,volume 65))

  • 160 Accesses

Abstract

Reviewing the program for this training course, it is easy to realize that many of the lectures are somehow related to the topics of the present paper. (See lectures of Cardinali, Demaine, Moore, Quay). Therefore, it is difficult to find the proper boundary between the different aspect of similar research problems. In this view, the general morphological, physiological and biochemical changes in the central nervous system, due to the action of the pineal hormones, will be touched upon only very briefly. Therefore, I would like to concentrate rather on the problem of the site and mechanism of action of pineal hormones by which this gland influences the function of the neuroendocrine system. I will attempt to summarize the data indicating a central nervous point of attack of pineal indoles that influence the secretion of the hypothalamic releasing hormones.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anton Tay F., 1974, Melatonin: effects on brain function, Adv. Biochem. Psychooharmacol., 11: 315.

    CAS  Google Scholar 

  • Anton Tay F., Chou C., Anton S., Wurtman R.J., 1968, Brain serotonin concentration: Elevation following intraperitoneal administration of melatonin, Science, 162: 277.

    Article  PubMed  CAS  Google Scholar 

  • Ariens Kappers J., 1971, The pineal organ: an introduction, in: The pineal gland. A Ciba Foundation Symposium, Wolstenholme G.E.W., Knight J., eds., Churchill Livingstone, Edinburgh and London, p. 3.

    Google Scholar 

  • Bacon A., Sattler C., Martin J.E., 1981, Melatonin effect on the hamster pituitary response to LHRH, Biol, Reprod. 24: 993.

    Article  CAS  Google Scholar 

  • Bagnara J.T., 1963, The pineal and the body lightening reaction of larval amphibiens, Gener. comp. Endocrin. 3: 86.

    Article  CAS  Google Scholar 

  • Cardinali D.P., Vacas M.J., Boyer E.E., 1978, High affinity of melatonin in bovine medial basal hypothalamus, IRCS Med. Sci. 6: 357.

    CAS  Google Scholar 

  • Barbanti Silva C., Trentini G.P., 1965, Modificazione della neurosecrezione e della attivita acetilcolinesterasica dell’ ipotalamo anteriore di ratta albina dopo asportazione del ganglio cervicale superiore, Arch, Vecchi Anat. pat., 45: 807.

    CAS  Google Scholar 

  • Cardinali D.P., 1975, Changes in hypothalamic neurotransmitter uptake following pinealectomy, superior cervical ganglionectomy or melatonin administration to rats, Neuroendocrinology, 19: 91.

    Article  PubMed  CAS  Google Scholar 

  • Cardinali D.P., Hyyppä M.T., Wurtman R.J., 1973, Fate of intracysternally injected melatonin in the rat brain, Neuro-endocrinology, 12: 30.

    CAS  Google Scholar 

  • Demaine C., Kann C.H., 1979a, Modification of the electrical activity of hypothalamic neurons by pineal indoles, Progr. Brain Res., 52: 373.

    Article  CAS  Google Scholar 

  • Demaine C., Kann A.C., 1979b, Hypothalamic neurons as possible target cells for pineal indoles, J. Physiol. CLond, 291: 49.

    Google Scholar 

  • De Vries R.A.C., 1972, Influence of pinealectomy on hypothalamic magnocellular neurosecretory activity in the female rat during normal light conditions, light-induced persistent oetrus, and after gonadectomy, Neuroendocrinologv, 9: 244.

    Article  Google Scholar 

  • Flerkó B., 1954, Zur hypothalamischen Steuerung der gonadotrophen Funktion der Hypophyse, Acta Morph. Acad. Sci. Hung., 4: 475.

    Google Scholar 

  • Fraschini F., Collu R., Martini L., 1971, Mechanism of inhibitory action of pineal principles on gonadotrophin secretion, in: The pineal gland. A Ciba Foundation Symposium, Wolstenholme G.E.W., Knight J., eds., Churchill Livingstone, Edinburgh and London. p. 259.

    Google Scholar 

  • Frehn J.L., Urry R.L., Ellis L.C., 1974, Effect of melatonin and short photoperiod on A 4-reductase activity in liver and hypothalamus of the hamster and the rat, J. Endocr., 60: 507.

    Article  PubMed  CAS  Google Scholar 

  • Hagino N., Tima L., Flerkó B., 1914, Ovulation inducing capacity of serotonin in persistent oestrous rats, Acta biol. Acad. Sci. Hung., 25: 327.

    Google Scholar 

  • Héry M., Dusticier G., Faudon M., Barrit M.C., 1980, Kinetic study of serotonin metabolism in the suprachiasmatic nucleus of the rat: neuroendocrine incidence, in: The serotoninergic neuron, Calas A., ed., J. Physiol. CParis., p. 497.

    Google Scholar 

  • Hewing M., 1980, Cerebrospinal fluid-contacting area in the pineal recess of the vole (Microtus agrestis), guinea pig CCavia cobaya) and rhesus monkey CMacaca mulatta), Cell Tis. Res., 209: 473.

    CAS  Google Scholar 

  • Hillarp N.A., 1949, Studies on the localization of hypothalamic centers controlling the gonadotrophic function of the hypophysis, Acta endocrinol. CKbh., 2: 11.

    CAS  Google Scholar 

  • Kamberi I.A., 1974, Catecholaminergic, indoleaminergic and cholinergie pathways and the hypothalamic-hypophysiotrophic neurohormones involved in control of gonadotrophin secretion, in: Endocrinology of Sex,Dörner G., ed., Barth, Leipzig, p. 166.

    Google Scholar 

  • Kopp N., Chaustrat B., Tappar M., 1980 Evidence for the presence of melatonin in the human brain, Neurosci. Lett. 19: 237.

    Article  PubMed  CAS  Google Scholar 

  • Marczynski T.J., Yamaguchi N., Ling G.M., Grodinzska L., 1964, Sleep induced by the administration of melatonin (5methoxy-N-acetyltryptamine) to the hypothalamus in unrestrained cats, Experientia (Basel), 20: 435.

    Article  CAS  Google Scholar 

  • Martin J.E., Engel J.N., Klein D.C., 1977, Inhibition of the in vitro pituitary response to luteinizing hormone-releasing hormone by melatonin, serotonin, and 5-methoxytryptamine, Endocrinology, 100: 675.

    Article  PubMed  CAS  Google Scholar 

  • Martin J.E., Sattler C., 1979, Developmental loss of the acute inhibitory effect of melatonin on the in vitro pituitary luteinizing hormone and follicle-stimulating hormone responses to luteinizing hormone-releasing hormone, Endocrinology, 105: 1007.

    Article  PubMed  CAS  Google Scholar 

  • Martin J.E., McKellar S., Klein D.C., 1980a Melatonin inhibition of the in vivo pituitary response to luteinizing hormone-releasing hormone in the neonatal rat, Neuroendocrinology 31: 13.

    Article  PubMed  CAS  Google Scholar 

  • Martin J.E., Kirk N.L., Klein D.C., 1980b, Effects of 6hydroxy-, 6-fluoro-, and 4–6-difluoromelatonin on the in vitro pituitary response to luteinizing hormone-releasing hormone, Endocrinology, 106: 398.

    Article  PubMed  CAS  Google Scholar 

  • Martini L., Fioretti M.C., 1971, Behavioural effects of pineal principles. in: The pineal gland. A Ciba Foundation Symposium,Wolstenholme G.E.w., and Knight J., eds., Churchill Livingstone, Edinburgh and London, p. 368.

    Google Scholar 

  • Mess B., Fraschini F., Motta M., Martini L., 1967, The topography of the neurons synthesizing the hypothalamic releasing factors,in: Proc. Second Int. Congr. Hormonal Steroids, Martini L., ed., Excerpta Med. Int. Congr. Ser. 132: 1004

    Google Scholar 

  • Mess B., Heizer A., Tdth A., Tima L., 1971, Luteinization induced by pinealectomy in the polyfollicular ovaries of rats bearing anterior hypothalamic lesions, in: The pineal gland. A Ciba Foundation Symposium, Wolstenholme E.G.W., and Knight J., eds., Churchill Livingstone, Edinburgh and London. p. 229.

    Google Scholar 

  • Mess B., Tima L., Trentini G.P., 1973, The role of pineal principles in ovulation Progr. Brain Res. 39: 251.

    Article  CAS  Google Scholar 

  • Mess B., Trentini G.P., Kovacs L., De Gaetani C.F., 1975. Melatonin, cerebrospinal fluid, pineal gland interrelationships, in: Brain-Endocrine Interaction II. The ventricular system in neuroendocrine mechanisms, Knigge K.M., Scott D.E., Kobayashi H., Ishii S., eds., Karger, Basel p. 355.

    Google Scholar 

  • Mess B., Trentini G.P., Tima L., 1978, Role of the pineal gland in the regulation of ovulation. Stud. Biol. Hung. Vol. 16. Akadémiai Kiadó, Budapest

    Google Scholar 

  • Mess B., Trentini G•P., Ruzsâs Cs., De Gaetani C.F., 1979, Possible role of the brain serotoninergic neuron system in inducing ovulation in the light-induced constant estrous anovulatory syndrome, in: Recent advances in reproduction and regulation of fertility, Talwar G.P., ed., Elsevier, Amsterdam p. 37.

    Google Scholar 

  • Mieno M., Yamashita E., Iimori M., Yamashita K., 1978, An inhibitory effect of melatonin on the luteinizing hormone releasing activity of luteinizing hormone releasing hormone in immature male dogs, J. Endocr., 78: 283.

    Article  PubMed  CAS  Google Scholar 

  • Mieno M., Yamashita E., Koba H., Iimori M., Yamashita K., 1980, Combined effects of melatonin and arginine-vasotocin on the canine pituitary response to luteinizing hormone releasing hormone. IRCS Med. Sci., 8: 458.

    CAS  Google Scholar 

  • Mieno M., Ogawa E., Tanaka R., Iimori M., Yamashita K., 1981, Effect of 5-Methoxytryptophol on the action of luteinizing hormone releasing hormone in the release of luteinizing hormone and its competition with melatonin, IRCS Med. Sci., 9: 87.

    CAS  Google Scholar 

  • Niles L.P., Wong Y.W., Miskra R.K., Brown G.M., 1979, Melatonin receptors in brain, Europ. J. Pharmacol., 55: 219

    Google Scholar 

  • Orsi L., Demari J.H., Nagle C.A., Cardinali D.P., Rosner J.M., 1973, Effects of melatonin on the synthesis of proteins by the rat hypothalamus, hypophysis and pineal organ, J. Endocr. 58: 131.

    Article  PubMed  CAS  Google Scholar 

  • Orts R.J., Bruot B.C., Sartin J.L., 1980, Inhibitory properties of.a bovine pineal tripeptide, Threonylseryellisine, on serum Follicle-Stimulating Hormone, Neuroendocrinolog7, 30: 92.

    Article  Google Scholar 

  • Palkovits M., Arimura A., Brownstein M., Schally A.V., Saavedra J.M., 1974, Luteinizing Hormone Releasing Hormone CLHRH) content of the hypothalamic nuclei in rat, Endocrinology, 95: 554.

    Article  PubMed  CAS  Google Scholar 

  • Palkovits M., Brownstein M., Saavedra J.M., 1974, Serotonin content of the brain stem nuclei in the rat, Brain Res., 80: 237.

    Article  PubMed  CAS  Google Scholar 

  • Reisman G., Brown Grant K., 1977, The “suprachiasmatic syndrome”. Endocrine and behavioural abnormalites following lesions of the suprachiasmatic nuclei in the female rat, Froc. Roy. Soc., 198: 297

    Google Scholar 

  • Reiter R.J., Vaughan M.K., Bleak D.E., Johnson Z.Y., 1974, Melatonin: its inhibition of pineal antigonadotrophic activity in male hamsters, Science, 185: 1169.

    Article  PubMed  CAS  Google Scholar 

  • Roizen M.F., Jacobowitz D.M., 1976, Studies on the origin of innervation of the noradrenergic area bordering the nucleus raphe dorsalis, Brain Res., 101: 561.

    Article  PubMed  CAS  Google Scholar 

  • Ruzsâs Cs., Trentini G.P., Mess B., 1977, The role of the pineal gland in the regulation of LA release in rats with different types of the anovulatory syndrome, Endokrinologie., 70: 142

    Google Scholar 

  • Ruzsâs Cs., De Gaetani C.F., Criscuolo M., Mess B., Trentini G.P., 1981, Possible role of the midbrain serotoninergic raphe nuclei in the regulation of ovulation exerted by melatonin in the rat, Neuroendocr. letters, 3: 331.

    Google Scholar 

  • Ruzsâs Cs., De Gaetani C.F., Criscuolo M., Trentini G.P., 1982,Effect of selective 5,7-dihydroxytryptamine lesions of the midbrain serotoninergic neuron system on ovarian cyclicity maintained by melatonin in the continuous light exposed rat, In press.

    Google Scholar 

  • Samson W.K., McCann S.M., Chud L., Dudley C.A., Moss R.Z., 1980, Intra and extrahypothalamic Luteinizing hormone releasing hormone CLHRH) distribution in the rat with special reference to single neurons responsible to LHRH, Neuroendocrinologv, 31: 66

    Article  CAS  Google Scholar 

  • Sheridan M.N. Reiter R.J., Jacobs J.J., 1969, An intersting anatomical relationship between the hamster pineal gland and the ventricular system of the brain, J. Endocrin., 45: 131.

    Google Scholar 

  • Tima L., Trentini G.P., Mess B., 1973, Effect of serotonin on ovulation induced by pinealectomy in anovulatory frontal deafferented rats, Neuroendocrinology, 12: 149.

    Article  PubMed  CAS  Google Scholar 

  • Trentini G.P., Time L., Mess B., 1973, Effects of bilateral cervical sympathectomy on ovulation and fertility of rats bearing frontal hypothalamic deafferentation and anovulatory syndrome, Hormone Res., 4: 349.

    Article  PubMed  CAS  Google Scholar 

  • Trentini G.P., De Gaetani C.F., Martini L., Mess B., 1976, Changes in luteinizing hormone levels following pinealectomy and bilateral cervical ganglionectomy in constant oestrous anovulatory rat, Proc. Soc. exp. Biol. Med., 153: 490.

    Article  PubMed  CAS  Google Scholar 

  • Trentini G.P., Mess B., De Gaetani C.F., Ruzsas Cs., 1978, Effect of melatonin and possible role of the brain serotoninergic system, J. endocr. Invest., 1: 305.

    PubMed  CAS  Google Scholar 

  • Trentini G.P., Mess B., De Gaetani C.F., Poggioli R., Ferrari P., Di Gregorio C., 1981, The role of melatonin and brain serotoninergic system in the maintenance of rat ovarian cyclicity, in: Pineal function, Matthews C.D.,and Seamark R.F., eds., Elsevier, Amsterdam p. 77.

    Google Scholar 

  • Ungerstedt U., 1971, Stereotaxic mapping of the monoamine pathways in the rat brain, Acta Physiol. Scand., 367: 1.

    CAS  Google Scholar 

  • Urry R.L., Ellis L.C., 1975, Monoamine oxydase activity of the hypothalamus and pituitary: Alterations after pinealectomy, changes in photoperiod, or additions of melatonin in vitro, Experientia C Basel., 31: 891.

    Article  CAS  Google Scholar 

  • Weinberg U., Weitzman E.D., Fukushima D.K., Cancel G.F., Rosenfeld R.S., 1980, Melatonin does not suppress the pituitary luteinizing hormone response to Luteinizing Hormone-Releasing Hormone in Men, J. Clin Endocrinol. Metab., 51: 161

    Google Scholar 

  • Withyachumnarnkul B., Knigge K.M., 1980, Melatonin con- centration in cerebrospinal fluid, peripheral plasma and plasma of the confluence sinuum of the rat, Neuroendocrinology, 30: 382.

    Article  PubMed  CAS  Google Scholar 

  • Wurtman R.J., Axelrod J., Fisher J.E., 1964, Melatonin synthesis in the pineal gland. Effect of light mediated by the sympathetic nervous system, Science, 143: 1328.

    Article  CAS  Google Scholar 

  • Yamashita K., Mieno M., Shimizu T., Yamashita E., 1978, Inhibition by melatonin of the pituitary response to luteinizing hormone releasing hormone in vivo, J. Endocr., 76: 487.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer Science+Business Media New York

About this chapter

Cite this chapter

Mess, B., Trentini, G.P., Ruzsás, C., De Gaetani, C.F. (1983). Pineal-Hypothalamic Interactions: Possible Role of the Monoaminergic Neuron System. In: Axelrod, J., Fraschini, F., Velo, G.P. (eds) The Pineal Gland and its Endocrine Role. NATO Advanced Science Institutes Series, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1451-7_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-1451-7_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1453-1

  • Online ISBN: 978-1-4757-1451-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics