Pineal-Hypothalamic Interactions: Possible Role of the Monoaminergic Neuron System

  • B. Mess
  • G. P. Trentini
  • C. Ruzsás
  • C. F. De Gaetani
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 65)


Reviewing the program for this training course, it is easy to realize that many of the lectures are somehow related to the topics of the present paper. (See lectures of Cardinali, Demaine, Moore, Quay). Therefore, it is difficult to find the proper boundary between the different aspect of similar research problems. In this view, the general morphological, physiological and biochemical changes in the central nervous system, due to the action of the pineal hormones, will be touched upon only very briefly. Therefore, I would like to concentrate rather on the problem of the site and mechanism of action of pineal hormones by which this gland influences the function of the neuroendocrine system. I will attempt to summarize the data indicating a central nervous point of attack of pineal indoles that influence the secretion of the hypothalamic releasing hormones.


Luteinizing Hormone Pineal Gland Choroid Plexus Dorsal Raphe Melatonin Treatment 
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  1. Anton Tay F., 1974, Melatonin: effects on brain function, Adv. Biochem. Psychooharmacol., 11: 315.Google Scholar
  2. Anton Tay F., Chou C., Anton S., Wurtman R.J., 1968, Brain serotonin concentration: Elevation following intraperitoneal administration of melatonin, Science, 162: 277.PubMedCrossRefGoogle Scholar
  3. Ariens Kappers J., 1971, The pineal organ: an introduction, in: The pineal gland. A Ciba Foundation Symposium, Wolstenholme G.E.W., Knight J., eds., Churchill Livingstone, Edinburgh and London, p. 3.Google Scholar
  4. Bacon A., Sattler C., Martin J.E., 1981, Melatonin effect on the hamster pituitary response to LHRH, Biol, Reprod. 24: 993.CrossRefGoogle Scholar
  5. Bagnara J.T., 1963, The pineal and the body lightening reaction of larval amphibiens, Gener. comp. Endocrin. 3: 86.CrossRefGoogle Scholar
  6. Cardinali D.P., Vacas M.J., Boyer E.E., 1978, High affinity of melatonin in bovine medial basal hypothalamus, IRCS Med. Sci. 6: 357.Google Scholar
  7. Barbanti Silva C., Trentini G.P., 1965, Modificazione della neurosecrezione e della attivita acetilcolinesterasica dell’ ipotalamo anteriore di ratta albina dopo asportazione del ganglio cervicale superiore, Arch, Vecchi Anat. pat., 45: 807.Google Scholar
  8. Cardinali D.P., 1975, Changes in hypothalamic neurotransmitter uptake following pinealectomy, superior cervical ganglionectomy or melatonin administration to rats, Neuroendocrinology, 19: 91.PubMedCrossRefGoogle Scholar
  9. Cardinali D.P., Hyyppä M.T., Wurtman R.J., 1973, Fate of intracysternally injected melatonin in the rat brain, Neuro-endocrinology, 12: 30.Google Scholar
  10. Demaine C., Kann C.H., 1979a, Modification of the electrical activity of hypothalamic neurons by pineal indoles, Progr. Brain Res., 52: 373.CrossRefGoogle Scholar
  11. Demaine C., Kann A.C., 1979b, Hypothalamic neurons as possible target cells for pineal indoles, J. Physiol. CLond, 291: 49.Google Scholar
  12. De Vries R.A.C., 1972, Influence of pinealectomy on hypothalamic magnocellular neurosecretory activity in the female rat during normal light conditions, light-induced persistent oetrus, and after gonadectomy, Neuroendocrinologv, 9: 244.CrossRefGoogle Scholar
  13. Flerkó B., 1954, Zur hypothalamischen Steuerung der gonadotrophen Funktion der Hypophyse, Acta Morph. Acad. Sci. Hung., 4: 475.Google Scholar
  14. Fraschini F., Collu R., Martini L., 1971, Mechanism of inhibitory action of pineal principles on gonadotrophin secretion, in: The pineal gland. A Ciba Foundation Symposium, Wolstenholme G.E.W., Knight J., eds., Churchill Livingstone, Edinburgh and London. p. 259.Google Scholar
  15. Frehn J.L., Urry R.L., Ellis L.C., 1974, Effect of melatonin and short photoperiod on A 4-reductase activity in liver and hypothalamus of the hamster and the rat, J. Endocr., 60: 507.PubMedCrossRefGoogle Scholar
  16. Hagino N., Tima L., Flerkó B., 1914, Ovulation inducing capacity of serotonin in persistent oestrous rats, Acta biol. Acad. Sci. Hung., 25: 327.Google Scholar
  17. Héry M., Dusticier G., Faudon M., Barrit M.C., 1980, Kinetic study of serotonin metabolism in the suprachiasmatic nucleus of the rat: neuroendocrine incidence, in: The serotoninergic neuron, Calas A., ed., J. Physiol. CParis., p. 497.Google Scholar
  18. Hewing M., 1980, Cerebrospinal fluid-contacting area in the pineal recess of the vole (Microtus agrestis), guinea pig CCavia cobaya) and rhesus monkey CMacaca mulatta), Cell Tis. Res., 209: 473.Google Scholar
  19. Hillarp N.A., 1949, Studies on the localization of hypothalamic centers controlling the gonadotrophic function of the hypophysis, Acta endocrinol. CKbh., 2: 11.Google Scholar
  20. Kamberi I.A., 1974, Catecholaminergic, indoleaminergic and cholinergie pathways and the hypothalamic-hypophysiotrophic neurohormones involved in control of gonadotrophin secretion, in: Endocrinology of Sex,Dörner G., ed., Barth, Leipzig, p. 166.Google Scholar
  21. Kopp N., Chaustrat B., Tappar M., 1980 Evidence for the presence of melatonin in the human brain, Neurosci. Lett. 19: 237.PubMedCrossRefGoogle Scholar
  22. Marczynski T.J., Yamaguchi N., Ling G.M., Grodinzska L., 1964, Sleep induced by the administration of melatonin (5methoxy-N-acetyltryptamine) to the hypothalamus in unrestrained cats, Experientia (Basel), 20: 435.CrossRefGoogle Scholar
  23. Martin J.E., Engel J.N., Klein D.C., 1977, Inhibition of the in vitro pituitary response to luteinizing hormone-releasing hormone by melatonin, serotonin, and 5-methoxytryptamine, Endocrinology, 100: 675.PubMedCrossRefGoogle Scholar
  24. Martin J.E., Sattler C., 1979, Developmental loss of the acute inhibitory effect of melatonin on the in vitro pituitary luteinizing hormone and follicle-stimulating hormone responses to luteinizing hormone-releasing hormone, Endocrinology, 105: 1007.PubMedCrossRefGoogle Scholar
  25. Martin J.E., McKellar S., Klein D.C., 1980a Melatonin inhibition of the in vivo pituitary response to luteinizing hormone-releasing hormone in the neonatal rat, Neuroendocrinology 31: 13.PubMedCrossRefGoogle Scholar
  26. Martin J.E., Kirk N.L., Klein D.C., 1980b, Effects of 6hydroxy-, 6-fluoro-, and 4–6-difluoromelatonin on the in vitro pituitary response to luteinizing hormone-releasing hormone, Endocrinology, 106: 398.PubMedCrossRefGoogle Scholar
  27. Martini L., Fioretti M.C., 1971, Behavioural effects of pineal principles. in: The pineal gland. A Ciba Foundation Symposium,Wolstenholme G.E.w., and Knight J., eds., Churchill Livingstone, Edinburgh and London, p. 368.Google Scholar
  28. Mess B., Fraschini F., Motta M., Martini L., 1967, The topography of the neurons synthesizing the hypothalamic releasing factors,in: Proc. Second Int. Congr. Hormonal Steroids, Martini L., ed., Excerpta Med. Int. Congr. Ser. 132: 1004Google Scholar
  29. Mess B., Heizer A., Tdth A., Tima L., 1971, Luteinization induced by pinealectomy in the polyfollicular ovaries of rats bearing anterior hypothalamic lesions, in: The pineal gland. A Ciba Foundation Symposium, Wolstenholme E.G.W., and Knight J., eds., Churchill Livingstone, Edinburgh and London. p. 229.Google Scholar
  30. Mess B., Tima L., Trentini G.P., 1973, The role of pineal principles in ovulation Progr. Brain Res. 39: 251.CrossRefGoogle Scholar
  31. Mess B., Trentini G.P., Kovacs L., De Gaetani C.F., 1975. Melatonin, cerebrospinal fluid, pineal gland interrelationships, in: Brain-Endocrine Interaction II. The ventricular system in neuroendocrine mechanisms, Knigge K.M., Scott D.E., Kobayashi H., Ishii S., eds., Karger, Basel p. 355.Google Scholar
  32. Mess B., Trentini G.P., Tima L., 1978, Role of the pineal gland in the regulation of ovulation. Stud. Biol. Hung. Vol. 16. Akadémiai Kiadó, BudapestGoogle Scholar
  33. Mess B., Trentini G•P., Ruzsâs Cs., De Gaetani C.F., 1979, Possible role of the brain serotoninergic neuron system in inducing ovulation in the light-induced constant estrous anovulatory syndrome, in: Recent advances in reproduction and regulation of fertility, Talwar G.P., ed., Elsevier, Amsterdam p. 37.Google Scholar
  34. Mieno M., Yamashita E., Iimori M., Yamashita K., 1978, An inhibitory effect of melatonin on the luteinizing hormone releasing activity of luteinizing hormone releasing hormone in immature male dogs, J. Endocr., 78: 283.PubMedCrossRefGoogle Scholar
  35. Mieno M., Yamashita E., Koba H., Iimori M., Yamashita K., 1980, Combined effects of melatonin and arginine-vasotocin on the canine pituitary response to luteinizing hormone releasing hormone. IRCS Med. Sci., 8: 458.Google Scholar
  36. Mieno M., Ogawa E., Tanaka R., Iimori M., Yamashita K., 1981, Effect of 5-Methoxytryptophol on the action of luteinizing hormone releasing hormone in the release of luteinizing hormone and its competition with melatonin, IRCS Med. Sci., 9: 87.Google Scholar
  37. Niles L.P., Wong Y.W., Miskra R.K., Brown G.M., 1979, Melatonin receptors in brain, Europ. J. Pharmacol., 55: 219Google Scholar
  38. Orsi L., Demari J.H., Nagle C.A., Cardinali D.P., Rosner J.M., 1973, Effects of melatonin on the synthesis of proteins by the rat hypothalamus, hypophysis and pineal organ, J. Endocr. 58: 131.PubMedCrossRefGoogle Scholar
  39. Orts R.J., Bruot B.C., Sartin J.L., 1980, Inhibitory properties of.a bovine pineal tripeptide, Threonylseryellisine, on serum Follicle-Stimulating Hormone, Neuroendocrinolog7, 30: 92.CrossRefGoogle Scholar
  40. Palkovits M., Arimura A., Brownstein M., Schally A.V., Saavedra J.M., 1974, Luteinizing Hormone Releasing Hormone CLHRH) content of the hypothalamic nuclei in rat, Endocrinology, 95: 554.PubMedCrossRefGoogle Scholar
  41. Palkovits M., Brownstein M., Saavedra J.M., 1974, Serotonin content of the brain stem nuclei in the rat, Brain Res., 80: 237.PubMedCrossRefGoogle Scholar
  42. Reisman G., Brown Grant K., 1977, The “suprachiasmatic syndrome”. Endocrine and behavioural abnormalites following lesions of the suprachiasmatic nuclei in the female rat, Froc. Roy. Soc., 198: 297Google Scholar
  43. Reiter R.J., Vaughan M.K., Bleak D.E., Johnson Z.Y., 1974, Melatonin: its inhibition of pineal antigonadotrophic activity in male hamsters, Science, 185: 1169.PubMedCrossRefGoogle Scholar
  44. Roizen M.F., Jacobowitz D.M., 1976, Studies on the origin of innervation of the noradrenergic area bordering the nucleus raphe dorsalis, Brain Res., 101: 561.PubMedCrossRefGoogle Scholar
  45. Ruzsâs Cs., Trentini G.P., Mess B., 1977, The role of the pineal gland in the regulation of LA release in rats with different types of the anovulatory syndrome, Endokrinologie., 70: 142Google Scholar
  46. Ruzsâs Cs., De Gaetani C.F., Criscuolo M., Mess B., Trentini G.P., 1981, Possible role of the midbrain serotoninergic raphe nuclei in the regulation of ovulation exerted by melatonin in the rat, Neuroendocr. letters, 3: 331.Google Scholar
  47. Ruzsâs Cs., De Gaetani C.F., Criscuolo M., Trentini G.P., 1982,Effect of selective 5,7-dihydroxytryptamine lesions of the midbrain serotoninergic neuron system on ovarian cyclicity maintained by melatonin in the continuous light exposed rat, In press.Google Scholar
  48. Samson W.K., McCann S.M., Chud L., Dudley C.A., Moss R.Z., 1980, Intra and extrahypothalamic Luteinizing hormone releasing hormone CLHRH) distribution in the rat with special reference to single neurons responsible to LHRH, Neuroendocrinologv, 31: 66CrossRefGoogle Scholar
  49. Sheridan M.N. Reiter R.J., Jacobs J.J., 1969, An intersting anatomical relationship between the hamster pineal gland and the ventricular system of the brain, J. Endocrin., 45: 131.Google Scholar
  50. Tima L., Trentini G.P., Mess B., 1973, Effect of serotonin on ovulation induced by pinealectomy in anovulatory frontal deafferented rats, Neuroendocrinology, 12: 149.PubMedCrossRefGoogle Scholar
  51. Trentini G.P., Time L., Mess B., 1973, Effects of bilateral cervical sympathectomy on ovulation and fertility of rats bearing frontal hypothalamic deafferentation and anovulatory syndrome, Hormone Res., 4: 349.PubMedCrossRefGoogle Scholar
  52. Trentini G.P., De Gaetani C.F., Martini L., Mess B., 1976, Changes in luteinizing hormone levels following pinealectomy and bilateral cervical ganglionectomy in constant oestrous anovulatory rat, Proc. Soc. exp. Biol. Med., 153: 490.PubMedCrossRefGoogle Scholar
  53. Trentini G.P., Mess B., De Gaetani C.F., Ruzsas Cs., 1978, Effect of melatonin and possible role of the brain serotoninergic system, J. endocr. Invest., 1: 305.PubMedGoogle Scholar
  54. Trentini G.P., Mess B., De Gaetani C.F., Poggioli R., Ferrari P., Di Gregorio C., 1981, The role of melatonin and brain serotoninergic system in the maintenance of rat ovarian cyclicity, in: Pineal function, Matthews C.D.,and Seamark R.F., eds., Elsevier, Amsterdam p. 77.Google Scholar
  55. Ungerstedt U., 1971, Stereotaxic mapping of the monoamine pathways in the rat brain, Acta Physiol. Scand., 367: 1.Google Scholar
  56. Urry R.L., Ellis L.C., 1975, Monoamine oxydase activity of the hypothalamus and pituitary: Alterations after pinealectomy, changes in photoperiod, or additions of melatonin in vitro, Experientia C Basel., 31: 891.CrossRefGoogle Scholar
  57. Weinberg U., Weitzman E.D., Fukushima D.K., Cancel G.F., Rosenfeld R.S., 1980, Melatonin does not suppress the pituitary luteinizing hormone response to Luteinizing Hormone-Releasing Hormone in Men, J. Clin Endocrinol. Metab., 51: 161Google Scholar
  58. Withyachumnarnkul B., Knigge K.M., 1980, Melatonin con- centration in cerebrospinal fluid, peripheral plasma and plasma of the confluence sinuum of the rat, Neuroendocrinology, 30: 382.PubMedCrossRefGoogle Scholar
  59. Wurtman R.J., Axelrod J., Fisher J.E., 1964, Melatonin synthesis in the pineal gland. Effect of light mediated by the sympathetic nervous system, Science, 143: 1328.CrossRefGoogle Scholar
  60. Yamashita K., Mieno M., Shimizu T., Yamashita E., 1978, Inhibition by melatonin of the pituitary response to luteinizing hormone releasing hormone in vivo, J. Endocr., 76: 487.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • B. Mess
    • 1
  • G. P. Trentini
    • 2
  • C. Ruzsás
    • 1
  • C. F. De Gaetani
    • 2
  1. 1.Department of AnatomyUniv. Med. SchoolPécsHungary
  2. 2.Department of Pathological AnatomyUniv. of ModenaItaly

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