Actions of the Pineal Gland and Melatonin on the Secretion of Cerebrospinal Fluid
Association of pineal function with flow or content of the cerebrospinal fluid (CSF) is a very old concept. In western civilization it came into prominent view with the writings of Herophilos of Alexandria (325–280 BC). However, then and through many subsequent centuries, this functional association was based essentially on philosophical speculations, which were contested and eventually discredited, bringing down with them many of the notions derived from, and dependent upon, them. This long and faltering early phase of “pinealology” corresponds to the first of the three periods in pineal research as summarized by Kappers (1979).
KeywordsLateral Ventricle Pineal Gland Choroid Plexus Golden Hamster Brain Water Content
Unable to display preview. Download preview PDF.
- Allen, D. J., Highison, G. J., Werneck, H., and Gentry, G., 1981, Morphological specializations of the ventricular surface of the choroidal epithelium and associated epiplexus cells, in: Eleventh International Congress of Anatomy: Advances in the Morphology of Cells and Tissues, p. 11, Alan R. Liss, New York.Google Scholar
- Arendt, J., Wetterberg, L., Heyden, T., Sizonenko, and Paunier, L., 1977, Radioimmunoassay of melatonin: Human serum and cerebrospinal fluid, Hormone Res., 8: 65.Google Scholar
- Decker, J. F., and Quay, W. B., in press, Stimulatory effects of melatonin on ependymal epithelium of choroid plexuses in Golden Hamsters, J. Neural Transmission.Google Scholar
- Rusted, R. F., and Reed, D. J., 1976, Regulation of cerebrospinal fluid potassium by the cat choroid plexus, J. Physiol., 259: 213.Google Scholar
- Koshiba, K., Oshima, H., and Uematsu, H., 1980, Fine structure of the choroid plexus in pigeon by transmission electron microscopy, J. Electron Microscopy, 29: 129.Google Scholar
- Lindvall, M., Edvinsson, L., and Owman, Ch., 1977, Histochemical, ultrastructural and functional evidence for a neurogenic control of cerebrospinal fluid production from the choroid plexus, Acta Physiol. Scand., Suppl. 452: 77.Google Scholar
- Mess, B., and Trentini, G. P., 1974, 3H-Melatonin level in cerebrospinal fluid and choroid plexus following intravenous administration of the labelled compound, Acta Physiol. Acad. Sci. Hung., 45: 225.Google Scholar
- Quay, W. B., 1970a, Experimental studies of brain water content and its 24-hour rhythmicity, Rassegna Neurologia Vegetativa, 24: 1.Google Scholar
- Quay, W. B., 1974a, “Pineal Chemistry in Cellular and Physiological Mechanisms,” Charles C Thomas, Springfield.Google Scholar
- Sahar, A., 1972a, Choroidal origin of cerebrospinal fluid, Israel J. Med. Sci., 8: 594.Google Scholar
- Westergaard, E., 1970, “The Lateral Cerebral Ventricles and Their Ventricular Walls,” Andelsbogtrykkeriet, Odense.Google Scholar
- Wright, E. M., 1972, Mechanisms of ion transport across the choroid plexus, J. Physiol., 226: 55.Google Scholar