Abstract
Trypanosoma cruzi is an obligate intracellular parasite of man and other mammals. In man, it produces a chronic infection which, in its more severe form, leads to cardiac damage and failure (Chagas disease).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Johnston, R. B, Godzik, C. A., and Cohn, Z. A., 1978, Increased superoxide anion production by immunologically activated and chemically elicited macrophages, J. Exp. Med. 148: 115–127.
Mackaness, G., 1964, The immunological basis of acquired cellular resistance, J. Exp. Med. 120: 105–120.
Nagakawara, A., De Santis, N., Nogueira, N., and Nathan, C., 1982, Lymphokines enhanced the capacity of human mononuclear phagocytes to secrete reactive oxygen intermediates, J. Clin. Invest. 70: 1042–1048.
Nathan, C. F., and Root, R. K., 1977, Hydrogen peroxide release from mouse peritoneal macrophages. Dependence on sequential activation and triggering, J. Exp. Med. 146: 1648–1662.
Nathan, C., Nogueira, N., Juangbhanich, C., Ellis, J., and Cohn, Z., 1979, Activation of macrophages in vivo and in vitro. Correlation between H2O2 release and killing of T. cruzi, J. Exp. Med. 149: 1056–1068.
Nogueira, N., and Cohn, Z. A., 1976, Trypanosoma cruzi: Mechanism of entry and intracellular fate in mammalian cells, J. Exp. Med. 143: 1402–1420.
Nogueira, N., and Cohn, Z. A., 1978, Trypanosoma cruzi: In vitro induction of macrophage microbicidal activity, J. Exp. Med. 148: 288–300.
Nogueira, N., Bianco, C., and Cohn, Z. A., 1975, Studies on the selected lysis and purification of Trypanosoma cruzi, J. Exp. Med. 142: 224–229.
Nogueira, N., Gordon, S., and Cohn, Z. A., 1977a, Trypanosoma cruzi: Modification of macrophage function during infection, J. Exp. Med. 146: 157.
Nogueira, N., Gordon, S., and Cohn, Z., 1977b, The immunological induction of macrophage plasminogen activator requires thymus-derived lymphocytes, J. Exp. Med. 146: 172–183.
Nogueira, N., Chaplan, S., and Cohn, Z. A., 1980, Trypanosoma cruzi: Factors modifying ingestion and fate of blood form trypomastigotes, J. Exp. Med. 152: 447–451.
Nogueira, N., Klebanoff, S., and Cohn, Z. A., 1982, T. cruzi: Sensitization to macrophage killing by eosinophil peroxidase, J. Immunol. 128: 1705.
Nogueira, N., Chaplan, S., Reesink, M., Tydings, J., and Cohn, Z. A., 1982, Trypanosoma cruzi: Induction of microbicidal activity in human mononuclear phagocytes, J. Immunol. 128: 2142–2146.
Unkeless, J. C., 1979, Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors, J. Exp. Med. 150: 580–596.
Unkeless, J. C., Gordon, S., and Reich, E., 1974, Secretion of plasminogen activator by stimulated macrophages, J. Exp. Med. 139: 834–850.
Williams, D. M., and Remington, J. S., 1977, Effects of human monocytes and macrophages on T. cruzi, Immunology 32: 19–23.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer Science+Business Media New York
About this chapter
Cite this chapter
Nogueira, N., Cohn, Z.A. (1984). Activation of Mononuclear Phagocytes for the Destruction of Intracellular Parasites: Studies with Trypanosoma cruzi. In: Adams, D.O., Hanna, M.G. (eds) Macrophage Activation. Contemporary Topics in Immunobiology, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1445-6_6
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1445-6_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1447-0
Online ISBN: 978-1-4757-1445-6
eBook Packages: Springer Book Archive