Alterations of Surface Properties by Macrophage Activation: Expression of Receptors for Fc and Mannose-Terminal Glycoproteins and Differentiation Antigens

  • R. Alan
  • B. Ezekowitz
  • S. Gordon
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 13)


The original definition of the activated macrophage described the altered function of these cells in antimicrobial activity and cell-mediated immunity (Mackaness, 1964), yet when the role of the macrophage in mammalian physiology and pathology is considered it is apparent that this definition may be too restricted. Inflammation, tissue remodeling, degradation, and turnover of normal body constituents and antitumor resistance could be more general expressions of enhanced macrophage functions. With these different roles in mind, it is necessary to consider the properties that distinguish acquired states of activation from the nonactivated or resident state.


Peritoneal Macrophage Macrophage Activation Phorbol Myristic Acetate Purify Protein Derivative Mouse Peritoneal Macrophage 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • R. Alan
    • 1
  • B. Ezekowitz
    • 1
  • S. Gordon
    • 1
  1. 1.Sir William Dunn School of PathologyOxford UniversityOxfordEngland

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