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The Effect of Glucose upon Reabsorptive Transport of Urate by the Kidney

  • Geoffrey Boner
  • Richard E. Rieselbach
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

The mechanism of the increase in urinary excretion of urate following hyperglycemia has been variously interpreted by different workers (1,2,3,4,5). Hyperglycemia and/or its consequences, in all probability inhibit the tubular reabsorption of urate. This inhibitory effect may be the result of:
  1. 1)

    the elevation of blood sugar per se,

     
  2. 2)

    an increase in filtered load of glucose with an associated acceleration of reabsorptive transport in that segment of the proximal tubule where glucose is primarily reabsorbed, or

     
  3. 3)

    the presence of glucose in tubular fluid in a distal segment of the proximal tubule in a concentration substantially greater than that usually present.

     

Keywords

Glomerular Filtration Rate Proximal Tubule Plasma Glucose Level Kidney Donor Oral Glucose Load 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • Geoffrey Boner
    • 1
  • Richard E. Rieselbach
    • 1
  1. 1.Nephrology ProgramUniversity of Wisconsin Medical SchoolMadisonUSA

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