Evidence for a Post-Secretory Reabsorptive Site for Uric Acid in Man

  • Herbert S. Diamond
  • Ezra Sharon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

Urinary uric acid is thought to be derived from two sources: uric acid filtered at the glomerulus and incompletely reabsorbed, and uric acid secreted by the renal tubules. The magnitude of the decrease in urinary uric acid which follows administration of pyrazinamide has been widely accepted as an estimate of the secretory component of urinary uric acid. This estimate is dependent upon the assumption that the site of uric acid reabsorption in the renal tubule is proximal to the site of its secretion. Recently, we have reported that total urinary uric acid excretion increases when urine flow rate increases, and have suggested that this was the result of decreased distal tubular reabsorption of uric acid.

Keywords

Uric Acid Renal Tubule Secretory Component Uric Acid Excretion Urinary Uric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • Herbert S. Diamond
    • 1
  • Ezra Sharon
    • 1
  1. 1.Downstate Medical CenterState University of New YorkBrooklynUSA

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