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Hypouricemia, Hypercalciuria, and Decreased Bone Density. A New Hereditary Syndrome

  • O. Sperling
  • A. Weinberger
  • I. Oliver
  • U. A. Liberman
  • A. de Vries
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

Genetically determined hypouricemia in man due to increased renal urate clearance is usually associated with additional renal tubular defects (1–3). Renal hypouricemia due to an isolated renal tubular defect has also been described but appears to be a rare condition (4,5). We report a new genetically determined syndrome in man, in which the renal hypouricemia is associated with idiopathic hypercalciuria and decreased bone density.

Keywords

Idiopathic Hypercalciuria Serum Ceruloplasmin Urinary Copper Decrease Bone Density Roentgen Examination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bishop C., Zimdahl V.T. and Talbott J.H. Proc. Soc. Exp. Biol. Med. 86:440, 1954.PubMedCrossRefGoogle Scholar
  2. 2.
    Baron D.N., Dent C.E., Harris H., Hert E.W. and Jepsen J.B. Lancet 271:421, 1956.PubMedCrossRefGoogle Scholar
  3. 3.
    Watts L.A. and Engle R.L. Jr. Arner. J. Med. 39:520, 1965.CrossRefGoogle Scholar
  4. 4.
    Praetorius E. and Kirk J.E. J. Lab. Clin. Med. 35:865, 1950.Google Scholar
  5. 5.
    Greene M.L., Marcus R., Aurbach G.D., Kazam E.S. and Seegmiller J.E. Amer. J. Med. 53:361, 1972.PubMedCrossRefGoogle Scholar
  6. 6.
    Steele T.H. and Rieselbach R.E. Amer. J. Med., 43:868, 1967.PubMedCrossRefGoogle Scholar
  7. 7.
    Sirota J.H., Yü T.F. and Gutman A.B. J. Clin. Invest. 31:692, 1952.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • O. Sperling
    • 1
  • A. Weinberger
    • 1
  • I. Oliver
    • 1
  • U. A. Liberman
    • 1
  • A. de Vries
    • 1
  1. 1.Rogoff-Wellcome Medical Research Institute and the Metabolic Unit of Department of Medicine DTel-Aviv University Medical School, Beilinson HospitalPetah TikvaIsrael

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