The Synthesis and Immuno-Enhancing Activity of 3-Butylazathioprine
As part of a programme of the design and testing of potential immunosuppressive and anticancer drugs, 9-butylazathioprine was synthesised (Chalmers, Knight & Atkinson, 1969) and shown to be an immunosuppressive agent (Chalmers, Gotjamanos, Rao, Knight & Atkinson, 1971; Chalmers, Burdorf & Murray, 1972). During the chemical synthesis of this compound from azathioprine and 1-iodobutane (Chalmers et al., 1969) small amounts of the 3-isomer (3-butylazathioprine) were formed. This paper describes the isolation and characterisation of this compound and reports the ability of the analogue to enhance the antibody response of mice to sheep red blood cells.
KeywordsAntibody Response Spleen Cell Antigenic Challenge Swiss Albino Mouse Deuterated Chloroform
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