The Synthesis and Immuno-Enhancing Activity of 3-Butylazathioprine

  • A. H. Chalmers
  • A. W. Murray
  • P. Verakalasa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

As part of a programme of the design and testing of potential immunosuppressive and anticancer drugs, 9-butylazathioprine was synthesised (Chalmers, Knight & Atkinson, 1969) and shown to be an immunosuppressive agent (Chalmers, Gotjamanos, Rao, Knight & Atkinson, 1971; Chalmers, Burdorf & Murray, 1972). During the chemical synthesis of this compound from azathioprine and 1-iodobutane (Chalmers et al., 1969) small amounts of the 3-isomer (3-butylazathioprine) were formed. This paper describes the isolation and characterisation of this compound and reports the ability of the analogue to enhance the antibody response of mice to sheep red blood cells.

Keywords

Antibody Response Spleen Cell Antigenic Challenge Swiss Albino Mouse Deuterated Chloroform 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Braun, W., Ishizuka, M., Yajima, Y., Webb, D. & Winchurch, R. (1971). In ‘Biological effects of polynucleotides’ p. 139. R.F. Beers & W. Braun (editors), Springer-Verlag, Berlin, Heidelberg, New York.CrossRefGoogle Scholar
  2. Chalmers, A.H., Burdorf, T. & Murray, A.W. (1972). Biochem Pharmacol. 21, 2662.CrossRefGoogle Scholar
  3. Chalmers, A.H., Gotjamanos, M.M., Rao, M.M., Knight, P.R. & Atkinson, M.R. (1971). J. Surg Res. 11, 284.PubMedCrossRefGoogle Scholar
  4. Chalmers, A.H., Knight, P.R. & Atkinson, M.R. (1969). Aust J. exp Biol med Sci. 47, 263.PubMedCrossRefGoogle Scholar
  5. Elion, G.B. (1957). In ‘The chemistry and biology of purines’ p. 46. G.E.W. Wolstenholme and CM. O’Connor (editors), Ciba Foundation.Google Scholar
  6. Hiu, I.J. (1972). Nature, New Biology 238, 241.Google Scholar
  7. Jerne, N.K. & Nordin, A.A. (1963). Science 140, 405.CrossRefGoogle Scholar
  8. Renoux, G. & Renoux, M. (1972). Nature, New Biology 240, 217.CrossRefGoogle Scholar
  9. Schwartz, R.S. (1968). In ‘Human transplantation’ p. 440. F. Rappaport and J. Dausset (editors), Gurne & Stratton, Inc., New York.Google Scholar
  10. Skoog, F., Hamzi, H.Q., Szweykowska, A.M., Leonard, N.J., Carraway, K.L., Fujii, T., Helgeson, J.P. & Leoppky, R.N. (1967). Phytochem. 6, 1169.CrossRefGoogle Scholar
  11. Townsend, L.B., Robins, R.K., Leoppky, R.N. & Leonard, J. (1964). J. Am. Chem Soc. 86, 5320.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • A. H. Chalmers
    • 1
  • A. W. Murray
    • 1
  • P. Verakalasa
    • 1
  1. 1.School of Biological SciencesFlinders University of South AustraliaBedford ParkAustralia

Personalised recommendations