Urinary Excretion of 6 Hydroxylated Metabolite and Oxypurines in a Xanthinuric Man Given Allopurinol or Thiopurinol
Xanthinuria is characterized by a large urinary excretion of oxypurine (xanthine + hypoxanthine) which replaces uric acid at the end product of purine metabolism. Patients with xanthinuria are very deficient in xanthine oxidase activity. This rare metabolic disorder may be of interest for both information: 1) the contribution of xanthine oxidase in the 6 hydroxylation of 4-hydroxy-pyrazolo (3,4-d) pyrimidine [(Pyrazolo (3,4-d) pyrimidine = PP)]: allopurinol and 4-thio-pyrazolo (3,4-d) pyrimidine: thiopurinol. 2) the contribution of their nucleotides (allo and thiopurinol ribonucleotide) to the reduction of biosynthesis de novo of purine.
KeywordsUrinary Excretion Xanthine Oxidase Normal Renal Function Purine Metabolism Xanthine Oxidase Activity
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