The Effect of Allopurinol on Oral Purine Absorption and Excretion in the Pig

  • H. A. Simmonds
  • A. Cadenhead
  • A. S. Jones
  • P. J. Hatfield
  • J. S. Cameron
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Abstract

Allopurinol therapy in hyperuricaemic man has been shown to be advantageous from two points of view. Firstly, it reduces urinary uric acid excretion and increases the excretion of the precursor purines xanthine and, to a lesser extent, hypoxanthine. In addition, total urinary purine excretion (the sum of these three) may be reduced by as much as 50% during allopurinol therapy (1). This latter effect has been attributed to the formation of nucleotides of either hypoxanthine (1) or allopurinol itself (2), which in turn exert a “feed back” inhibitary effect on the first enzyme of de novo purine synthesis.

Keywords

Uric Acid Acid Excretion Purine Synthesis Uric Acid Excretion Urinary Uric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • H. A. Simmonds
    • 1
    • 2
  • A. Cadenhead
    • 1
    • 2
  • A. S. Jones
    • 1
    • 2
  • P. J. Hatfield
    • 1
    • 2
  • J. S. Cameron
    • 1
    • 2
  1. 1.Guy’s Hospital and Rowett Research InstituteLondonUK
  2. 2.Guy’s Hospital and Rowett Research InstituteBucksburn, AberdeenshireUK

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