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Purine and Pyrimidine Biosynthesis in Neurospora Crassa and Human Skin Fibroblasts. Alteration by Ribosides and Ribotides of Allopurinol and Oxipurinol

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Purine Metabolism in Man

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 41))

Abstract

Allopurinol and oxipurinol inhibit according to Kelley et al. (1,2) both de novo purine and pyrimidine biosynthesis in human fibroblast cultures. This effect (at least at higher concentrations) was shown not to be dependent on the presence of xanthine oxidase or HGPRTase, so that it has to be attributed to some other mechanism than inhibition by allopurinol-ribonucleotide.

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References

  1. Kelley, W.N., and J.B. Wyngaarden J. Clin. Invest. 49, 602 (1970)

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  2. Kelley, W.N., I.H. Pox, T.D. Beardmore and J.C. Meade Annals New York Acad. Sciences 179, 588 (1971)

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  3. Rosenbloom, P.M., J.P. Henderson, I.C. Caldwell, W.N. Kelley and J.E. Seegmiller J. Biol. Chemistry 243, 1166 (1968)

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  4. Utter, M.P., in P.D. Boyer, H. Lardy and K. Myrbäck (Editors), The Enzymes, Vol II., Academic Press, New York, 78 (1960)

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  5. Elion, G.B., Kovensky, A., and Hitchings, G. H. Biochem. Pharmacol. 15, 863 (1966)

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Author information

Authors and Affiliations

  1. Medical Polyclinic, University of Munich, Pettenkoferstrasse 8a, Munich 2, D-8, Germany

    W. Kaiser & K. Stocker

Authors
  1. W. Kaiser
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  2. K. Stocker
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Editor information

Editors and Affiliations

  1. Division of Metabolic Disease, Rogoff-Wellcome Medical Research Institute, Beilinson Hospital, Petah-Tikva, Israel

    Oded Sperling  & Andre De Vries  & 

  2. Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA

    James B. Wyngaarden

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© 1974 Springer Science+Business Media New York

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Kaiser, W., Stocker, K. (1974). Purine and Pyrimidine Biosynthesis in Neurospora Crassa and Human Skin Fibroblasts. Alteration by Ribosides and Ribotides of Allopurinol and Oxipurinol. In: Sperling, O., De Vries, A., Wyngaarden, J.B. (eds) Purine Metabolism in Man. Advances in Experimental Medicine and Biology, vol 41. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-1433-3_32

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  • DOI: https://doi.org/10.1007/978-1-4757-1433-3_32

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-1435-7

  • Online ISBN: 978-1-4757-1433-3

  • eBook Packages: Springer Book Archive

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