Reduced Renal Ammoniagenesis in Primary Gout
The rate of NH3 diffusion is influenced by (1) the transtubular pH gradient, (2) the availability of titratable acid precursors, and (3) the urine flow rates. In our subjects for the present study of urinary excretion of titratable acid, NH+ 4, and uric acid, urine samples were collected as a rule from 6:30 A. M. to 8:30 A. M. after an overnight fast, both the gouty and the non-gouty subjects alike. the urine flow rates were more or less in the same range, approximately 1.0 ± 0.3 ml/min.
KeywordsUric Acid Titratable Acid Urine Flow Rate Acid Loading Urinary Uric Acid
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