Withdrawal of Allopurinol in Patients with Gout
A few years ago the possibility was raised that allopurinol therapy might lead to the incorporation of abnormal genetic material into cell nuclei. Another potential hazard was suggested by the finding of crystals of allopurinol and oxypurinol in muscle biopsy specimens from patients taking allopurinol. It subsequently appears that the first eventuality does not in fact occur and that the second is of no clinical significance. At the time, however, it was thought to be reasonable to determine the effect of discontinuing allopurinol therapy in gout patients who were not over-producers of uric acid and whose renal function was not impaired.
KeywordsRenal Function Uric Acid Potential Hazard Gouty Arthritis Purine Metabolism
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