A Systems Analysis—Thermodynamic View of Cellular and Organismic Aging

  • Jaime Miquel
  • Angelos C. Economos
  • John E. JohnsonJr.


Major theories of aging usually focus on senescent failure in important physiological systems (neuroendocrine, immunological, etc.) or specific molecular mechanisms such as DNA loss, enzyme inactivation, or macromolecular cross-linkage. Seldom is an attempt made to integrate the data using a systems analysis approach (Miller, 1978), and even more rarely is aging viewed as a thermodynamic process resulting from the interaction of an organism with the energy and matter of its environment (see Strehler, 1967; Sacher, 1967; Economos and Miguel, 1977; Miguel et al., 1979; Economos, 1982).


Subcellular Organelle Negative Geotaxis Free Radical Injury System Analysis Approach Hollow Arrow 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Jaime Miquel
    • 1
  • Angelos C. Economos
    • 2
  • John E. JohnsonJr.
    • 3
    • 4
  1. 1.Biomedical Research DivisionNASA Ames Research CenterMoffett FieldUSA
  2. 2.Genetics LaboratoryCatholic University of LouvainLouvain-la-NeuveBelgium
  3. 3.Department of NeurologyJohns Hopkins University School of MedicineBaltimoreUSA
  4. 4.National Institute on Aging, National Institutes of HealthBaltimore City HospitalsBaltimoreUSA

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