Abstract
Neurochemical changes which are associated with the development or expression of tolerance to or physical dependence on ethanol may be expected to display a time course of appearance and disappearance which correlates positively with the time course for tolerance or de-pendence. Previous studies of striatal dopaminergic receptor function indicated that ethanol-withdrawn mice displayed decreased physiological and biochemical responses to dopamine (DA) agonists, which could be best explained by postulating an inefficient coupling between DA receptors and various receptor-mediated processes, possibly as a result of ethanol-induced changes in neuronal membrane properties. The membrane-bound enzyme, (Na+-K+)ATPase, obtained from ethanol-withdrawn animals, displays an altered transition temperature and resistance to the effects of ethanol on enzyme activity. These changes also suggest compensatory alterations in neuronal membrane properties. All of these alterations show a time course of disappearance which corresponds to that for the disappearance of tolerance to the hypothermic and sedative effects of ethanol. Ethanol-withdrawn mice also display increased numbers of hippocampal muscarinic cholinergic receptors; however, the time course for the increase in receptor number appears to correlate with that of withdrawal symptomatology. Thus, compensatory changes in neuronal membrane properties in response to ethanol may be expressed via diverse functional changes.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Black, R. F., Hoffman, P. L. and Tabakoff, B., in press, Receptor-mediated dopaminergic function after ethanol. withdrawal, Alcoholism, Clin. and Exptl. Res. Charnock, J. S., Cook, D. A., Almeida, A. F. and To, R., 1973
Activation energy and phospholipid requirements of membrane-bound adenosine triphosphatases, Arch. Biochem. Biophys. 159:393–399.
Chin, J. H. and Goldstein, D. B., 1977, Drug tolerance in biomembranes: a spinlabel study of the effects of ethanol, Science 196: 684–685.
Chin, J. H., Parsons, L. M. and Goldstein, D. B., 1978, Increased cholesterol content of erythrocyte and brain membranes in ethanol-treated mice, Biochim. Biophys.,Acta,513: 358–363.
Clark, J. W., Kalant, H. and Carmichael, F. J., 1977, Effect of ethanol tolerance on release of acetylcholine and norepinephrine by rat cerebral cortex slices, Can. J. Physiol. Pharmacol., 55: 758768.
Cotman, C. W. and Matthews, D. A., 1971, Synaptic plasma membranes from rat brain synaptosomes: isolation and partial characterization, Biochim. Biophys. Acta, 249: 380–394.
Cotman, C. W., 1974, Isolation of synaptosomal and synaptic plasma membrane fractions, Meth. Enzymol., 31: 445–452, 1974.
Creese, I., Burt, D. P. and Snyder, S. H., 1977, Dopamine receptor binding enhancement accompanies lesion-induced behavioral super-sensitivity, Science, 197: 596–598.
DeKruyff, B., Van Dijck, P. W. M., Goldback, R. W., Demel, R. A. and van Deenen, L. L. M., 1973, Influence of fatty acid and sterol composition on the lipid phase transition and activity of membrane-bound enzymes in Acholeplasma Laidlawii, Biochim. Biophys. Acta, 330: 269–282.
Farias, R. N., Bloj, B., Morero, R. D., Sineriz, F. and Trucco, R. E., 1975, Regulation of allosteric membrane-bound enzymes through changes in membrane lipid composition, Biochim. Biophys. Acta, 415: 231–251.
Fields, J. Z., Roeske, W. R., Morkin, E. and Yamamura, H. I., 1978, Cardiac muscarinic cholinergic receptors. Biochemical identification and characterization, J. Biol. Chem., 253: 3251–3258.
Giorguieff, M. F., LeFloch, M. L., Glowinski, J. and Besson, M. J., 1977, Involvement of cholinergic presynaptic receptors of nicotinic and muscarinic types in the control of the spontaneous release of dopamine from striatal dopaminergic terminals in the rat, J. Pharmacol. Exptl. Ther., 200: 535–544.
Goldstein, D. B. and Israel, Y., 1972, Effects of ethanol on mouse brain (Na+K) activated adenosine triphosphatase, Life Science, 11 (II): 957–963.
Gruber, B., Dinovo, E. C., Noble, E. P. and Tewari, S., 1977, Ethanol-induced conformational changes in rat brain microsomal membranes, Biochem. Pharmacol., 26: 2181–2185.
Hoffman, P. L. and Tabakoff, B., 1977, Alterations in dopamine receptor sensitivity by chronic ethanol treatment, Nature, 268: 55 1553.
Jaffe, J. H. and Sharpless, S. K., 1968, Pharmacological denervation supersensitivity in the central nervous system: a theory of physical dependence, in: “The Addictive States,” A. Wikler, ed., Williams and Wilkins, Baltimore.
Javoy, F., Euvrard, C., Herbet, A. and Glowinski, J., 1977, Involve-ment of the dopamine nigrostriatal system in the picrotoxin effect on striatal acetylcholine levels, Brain Res, 126: 382–386.
Kurokawa, M., Kato, M. and Sakamoto, T., 1965, Distribution of sodiumplus-potassium-stimulated adenosine triphsophatase activity in isolated nerve-ending particles, Biochem. J., 97: 833–844.
Lenaz, G., Curatola, G. and Masotti, L., 1975, Perturbation of membrane fluidity, J. Bioenergetics, 7: 223–299.
Levental, M. and Tabakoff, B., in press, Sodium-potassium activated adenosine triphosphatase activity as a measure of neuronal mem- brane characteristics in ethanol-tolerant mice, J. Pharmacol. Exp. Ther.
Littleton, J. M., John G. R. and Grieve, S. J., 1979, Alterations in phospholipid composition in ethanol tolerance and dependence, Alcoholism Clin. Exptl. Res., 3: 50–56.
Ritzmann, R. F. and Tabakoff, B., 1976, Body temperature in mice: a quantitative measure of alcohol tolerance and physical dependence, J. Pharmacol. Exptl. Ther., 199: 158–170.
Seeman, P., 1972, The membrane actions of anesthetics and tranquilizers, Pharmacol. Rev., 24: 583–645.
Sporn, J. R., Harden, T. K., Wolfe, B. B. and Molinoff, P. B., 1976, ß-Adrenergic receptor involvement in 6-hydroxydopamine-induced supersensitivity in rat cerebral cortex, Science, 194: 624–626.
Tabakoff, B., Anderson, R. A. and Ritzmann, R. F., 1976, Brain acetaldehyde after ethanol administration, Biochem. Pharmacol., 25: 1305–1309.
Tabakoff, B., 1977, Neurochemical aspects of ethanol dependence, in: “Alcohol and Opiates: Neurochemical and Behavioral Mechanisms,” K. Blum, ed., Academic Press, New York.
Tabakoff, B. and Ritzmann, R. F., 1977, The effects of 6-hydroxydopamine on tolerance to and dependence on ethanol, J. Pharmacol. Exp. Ther., 203; 319–331.
Tabakoff, B. and Hoffman, P. L., 1978, Alterations in receptors controlling dopamine synthesis after chronic ethanol ingestion, J. Neurochem, 31: 1223–1229.
Tabakoff, B., Hoffman, P. L. and Ritzmann, R. F., 1978, Dopamine receptor function after chronic ingestion of ethanol, Life Sci., 23: 643–648.
Tabakoff, B. and Hoffman, P. L., 1979, Development of functional dependence on ethanol in dopaminergic systems, J. Pharmacol. Exptl. Ther., 208: 216–222.
Tabakoff, B., Marcus, M., and Fields, J. Z., 1979, Chronic ethanol feeding produces an increase in cholinergic receptors in mouse brain.
Yamamura, H. I. and Snyder, S. H., 1974, Muscarinic cholinergic binding in the rat brain, Proc. Natl. Acad. Sci., 71: 1725–1729.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hoffman, P.L., Levental, M., Fields, J.Z., Tabakoff, B. (1980). Receptor and Membrane Function in the Alcohol Tolerant/Dependent Animal. In: Thurman, R.G. (eds) Alcohol and Aldehyde Metabolizing Systems-IV. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1419-7_79
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1419-7_79
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1421-0
Online ISBN: 978-1-4757-1419-7
eBook Packages: Springer Book Archive