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The Effects of Ethanol on Developing Catecholamine Neurons

  • N. Detering
  • R. Collins
  • R. L. Hawkins
  • P. T. Ozand
  • A. M. Karahasan

Abstract

Significantly lower concentrations of norepinephrine were observed in whole brain and hypothalamus of pups exposed to ethanol pre- or post-natally as compared to controls. Dopamine levels were found to be unaltered in whole brain compared to controls although hypothalamus and corpus striatum demonstrated a decreased concentration in the experimental animals exposed to ethanol.

The reduced levels of these neurotransmitters observed in the hypothalamus could reflect a direct damage to norepinephrine neurons by pre- or post-natal exposure to ethanol. However, depressed dopamine levels in the corpus striatum indicate additional injury to dopamine neurons. Alternatively, a modulatory interaction between norepinephrinergic and dopaminergic systems may be operative in these offspring. The changes observed in catecholamines could not be explained by a single and simple mode of ethanol action in the developing rat.

Keywords

Corpus Striatum Norepinephrine Concentration Brain Norepinephrine Norepinephrine Neuron Catecholamine Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • N. Detering
    • 1
  • R. Collins
    • 1
  • R. L. Hawkins
    • 1
  • P. T. Ozand
    • 1
  • A. M. Karahasan
    • 1
  1. 1.Department of PediatricsUniversity of MarylandBaltimoreUSA

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