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Ethanol Elimination is Inherited in the Rat

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Alcohol and Aldehyde Metabolizing Systems-IV

Abstract

Ethanol metabolism was shown to be heritable in male and female Sprague-Dawley rats. In addition, the stimulated rate of ethanol elimination following 24 hours of treatment with ethanol was also shown to be heritable. F1 and F2 progeny for the two phenotypes (naive and adapted rates) resembled their selected parents rather than the unselected population.

Supported, in part, by AA-03624 and ARA-7905

Recipient of Cancer Development Award AA-00033.

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References

  • Bernstein, J., L. Videla, and Y. Israel, 1973, Metabolic alterations produced in the liver by chronic alcohol administration. II. Changes related to energetic parameters of the cell, Biochem. J., 134: 515.

    PubMed  CAS  Google Scholar 

  • Bleyman, MA., and R.G. Thurman, 1979, Comparison of acute and chronic ethanol administration on rates of ethanol elimination in the rat in vivo, Biochem. Pharmacol., 28: 2027.

    Article  PubMed  CAS  Google Scholar 

  • Crow, K.E., N.W. Cornell, and R.L. Veech, 1977, The role of alcohol dehydrogenase in governing rates of ethanol metabolism in rats, in: “Alcohol and Aldehyde Metabolizing Systems,” R.G. Thurman, J.R. Williamson, H.R. Drott, B. Chance, eds., Academic Press, New York.

    Google Scholar 

  • Eriksson, C.J.P., 1973, Ethanol and acetaldehyde metabolism in rat strains genetically selected for their ethanol preference, Biochem. Pharmacol., 22: 2283.

    Article  PubMed  CAS  Google Scholar 

  • Eriksson, K., 1968, Genetic selection for voluntary alcohol consumption in the albino rat, Science, 139: 739.

    Article  Google Scholar 

  • Eriksson, K., 1972, Behavioral and physiological differences among rat strains for their alcohol consumption, Ann. N.Y. Acad. Sci., 197: 32.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, D.B., 1973, Inherited differences in intensity of alcohol withdrawal reaction in mice, Nature, 245: 154.

    Article  PubMed  CAS  Google Scholar 

  • Goodwin, D., 1976, “Is Alcoholism Hereditary?”, Oxford University Press, New York.

    Google Scholar 

  • Hawkins, R., H. Kalant, and J. Khanna, 1966, Effects of chronic intake of ethanol on rate of ethanol metabolism, Can. J. Physiol. Pharm., 44: 241.

    Article  CAS  Google Scholar 

  • Kakihana, R., D.R. Brown, G.E. McClearn, and I.R. Tabershaw, 1966, Brain sensitivity to alcohol in inbred mouse strains, Science, 154: 1574.

    Article  PubMed  CAS  Google Scholar 

  • Lester, D., G.W.-J. Lin, N. Anadam, E.P. Riley, E.D. Worsham, and E.X. Freed, 1977, Selective breeding of rats for differences in reactivity to alcohol: An approach to an animal model of alcoholism. IT. Some behavioral and chemical measures, in: “Alcoholism and Aldehyde Metabolizing Systems,” R.G. Thurman, J.R. Williamson, H.R. Drott, B. Chance, eds., Academic Press, New York.

    Google Scholar 

  • Mendelson, J., S. Stein, and N. Mello, 1965, Effects of experimentally induced intoxication of ethanol -1-C14 in alcohol subjects, Metabolism, 14: 1255.

    Article  PubMed  CAS  Google Scholar 

  • Rodgers, D.A., 1972, Factors underlying differences in alcohol preference in inbred strains of mice, in: “The Biology of Alcoholism,” B. Kissin and H. Begleiter, eds., Plenum Press, New York.

    Google Scholar 

  • Sheppard, J.R., P. Albersheim, and G. McClearn, 1970, Aldehyde dehydrogenase and ethanol preference in mice, J. Biol. Chem., 245: 2876.

    PubMed  CAS  Google Scholar 

  • Speiss, E.B., 1977, “Genes in Populations,” John Wiley and Sons, New York.

    Google Scholar 

  • Thurman, R.G., W.R. McKenna, and T.B. McCaffrey, 1976, Pathways responsible for the adaptive increase in ethanol utilization following chronic treatment with ethanol: Inhibitor studies with the hemoglobin-free perfused rat liver, Mol. Pharmacol., 12: 156.

    PubMed  CAS  Google Scholar 

  • Thurman, R.G., T. Yuki, M.A. Bleyman, and G. Wendell, 1979, The adaptive increase in ethanol metabolism due to pretreatment with ethanol: A rapid phenomenon, Drug and Alcohol Dependence, 4: 119.

    Article  PubMed  CAS  Google Scholar 

  • Wendell, G.D., and R.G. Thurman, 1979, Effect of ethanol concentration on rates of ethanol elimination in normal and alcohol-treated rats in vivo, Biochem. Pharmacol., 28: 273.

    Article  PubMed  CAS  Google Scholar 

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© 1980 Springer Science+Business Media New York

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Thurman, R.G. (1980). Ethanol Elimination is Inherited in the Rat. In: Thurman, R.G. (eds) Alcohol and Aldehyde Metabolizing Systems-IV. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1419-7_68

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  • DOI: https://doi.org/10.1007/978-1-4757-1419-7_68

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1421-0

  • Online ISBN: 978-1-4757-1419-7

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