Dependence of Mitochondrial and Cytosolic ATP Systems on the Metabolic State of Perfused Rat Liver
Adenine nucleotides are the link between energy generating and energy utilizing processes in the cell. ATP is generated mainly in the mitochondria and is utilized mainly in the cytosol. It is transported across the mitochondrial membrane by a specific carrier in exchange for ADP. Since ATP and ADP are substrates and products of many reactions, most metabolic processes depend upon the phosphorylation potentials of the subcellular adenine nucleotide system. Moreover, ATP and ADP also act as modulators of several regulatory enzymes. A knowledge of their subcellular concentrations or phosphorylation potentials as reflected largely by the ATP/ADP ratios, therefore, will certainly increase our understanding of how metabolism is regulated in the living cell.
KeywordsAdenine Nucleotide Adenine Nucleotide Translocation Uncouple Agent Aldehyde Metabolize Cytosolic Phosphorylation
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