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Isozymes of Alcohol Dehydrogenase and Aldehyde Dehydrogenase in Japanese and their Role in Alcohol Sensitivity

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Alcohol and Aldehyde Metabolizing Systems-IV

Abstract

Racial differences in alcohol sensitivity have been described by many authors (Wolff, 1973; Ewing et al., 1974). Variant forms of alcohol metabolizing enzymes have been proposed to play an important role in sensitivity to alcohol associated with facial flushing and other subjective symptoms (Stamatoyannopoulos et al., 1975; Goedde et al., 1979b; Harada et al., 1979).

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References

  • Agarwal, D.P., S. Harada, I. Willers, and H.W. Goedde, 1978, Human alcohol dehydrogenase and aldehyde dehydrogenase isozymes in cultured fibroblasts and tissues, Arch. Genet., 51: 1.

    Google Scholar 

  • Asmussen, E., J. Hald, and V. Larsen, 1948, The pharmacological action of acetaldehyde on the human organism, Acta. Pharmacol. Toxicol., 4: 311.

    Article  CAS  Google Scholar 

  • Edwards, J.A., and E. Evans, 1967, Ethanol metabolism in subjects possessing typical and atypical liver alcohol dehydrogenase, Clin. Pharmacol. Ther., 8: 824.

    PubMed  CAS  Google Scholar 

  • Ewing, J.A., B.A. Rouse, and E.D. Pellizari, 1974, Alcohol sensitivity and ethnic background, Am. J. Psychiatry, 131: 206.

    PubMed  CAS  Google Scholar 

  • Goedde, H.W., D.P. Agarwal, S. Harada, 1979a, Alcohol metabolizing enzymes: Studies of isozymes-in human biopsies and cultured fibroblasts, Clin. Genet., 16: 29.

    Article  PubMed  CAS  Google Scholar 

  • Goedde, ‘H.W., S. Harada, and D.P. Agarwal, 1979b, Racial difference in alcohol sensitivity: A new hypothesis, Hum. Genet., 51: 331.

    Article  PubMed  CAS  Google Scholar 

  • Greenfield, N.J., and R. Pietruszko, 1977, Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes, Biochim. Biophys. Acta, 483: 35.

    Article  PubMed  CAS  Google Scholar 

  • Harada, S., D.P. Agarwal, and H.W. Goedde, 1978a, Application of gel isoelectric focusing and electrophoresis in the study of alcohol dehydrogenase and aldehyde dehydrogenase isozymes of human tissues and fibroblasts, in: “Electrophoresis 78”, Catsimpoolas, ed., Elsevier North Holland, Inc., NY.

    Google Scholar 

  • Harada, S., D.P. Agarwal, and H.W. Goedde, 1978b, Human liver alcohol dehydrogenase isozyme variation: Improved separation methods using prolonged high voltage starch gel electrophoresis and isoelectric focusing, Hum. Genet., 40: 215.

    Article  PubMed  CAS  Google Scholar 

  • Harada, S., D.P. Agarwal, and H.W. Goedde, 1978c4 Isozyme variations in acetaldehyde dehydrogenase (E.C. 1.2.1.3) in human tissues, Hum. Genet., 44: 181.

    Google Scholar 

  • Harada, S., S. Misawa, D.P. Agarwal, and H.W. Goedde, 1980, Liver alcohol dehydrogenase and aldehyde dehydrogenase in Japanese: Isozyme variation and its possible role in alcohol intoxication, Am. J. Human Genet. in press.

    Google Scholar 

  • Ijiri, I., 1974, Studies on the relationship between the concentrations of blood acetaldehyde and urinary catecholamine and the symptoms after drinking alcohol, Jap. J. Stud. Alcohol, 9: 35.

    CAS  Google Scholar 

  • Mizoi, Y., I. Ijiri, Y. Tatsuno, T. Kijima, S. Fujiwara, T. Adachi, and S. Hshida, 1979, Relationship between facial flushing and blood acetaldehyde levels after alcohol intake, Pharmacol. Biochem. Behay., 10: 303.

    Article  CAS  Google Scholar 

  • Schulz, W., S. Kreuzberg, H.G. Neymeyer, U. Schwarz, and P. Pachaly, 1976, Uber die Hayfigkeit der atypischen ADH in Leberbiopsie-material und den Einflub auf den Athanolumsatz in vivo, Kriminalistik und forensische Wissenschaften, 26: 109.

    CAS  Google Scholar 

  • Smith, M., D.A. Hopkinson, and H. Harris, 1973, Studies on the properties of the human alcohol dehydrogenase isozymes determined by the different loci ADH1, ADH2, and ADH3, Ann. Hum. Genet., 37: 49.

    Article  PubMed  CAS  Google Scholar 

  • Stamatoyannopoulos, G., S.H. Chen, and F. Fukui, 1975, Liver alcohol dehydrbgenase in Japanese: High population frequency of atypical form and its possible role in alcohol sensitivity, Am. J. Hum. Genet., 27: 789.

    PubMed  CAS  Google Scholar 

  • Von Wartburg, J.P., J. Papenberg, and H. Aebi, 1965, An atypical human alcohol dehydrogenase, Can. J. Biochem. 43:889.

    Google Scholar 

  • Wolff, P.H., 1973, Vasmotor sensitivity to alcohol in diverse Mongoloid populations, Am. J. Hum. Genet., 25: 193.

    PubMed  CAS  Google Scholar 

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Harada, S., Agarwal, D.P., Goedde, H.W. (1980). Isozymes of Alcohol Dehydrogenase and Aldehyde Dehydrogenase in Japanese and their Role in Alcohol Sensitivity. In: Thurman, R.G. (eds) Alcohol and Aldehyde Metabolizing Systems-IV. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1419-7_4

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  • DOI: https://doi.org/10.1007/978-1-4757-1419-7_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1421-0

  • Online ISBN: 978-1-4757-1419-7

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