Abstract
It is postulated that the effect of alcohol on trace element deposition during pregnancy is a long term one, requiring alcohol administration throughout the 21 days of gestation. Female Charles River rats (N=30) were given a semi-synthetic diet throughout pregnancy. Half the animals received alcohol (8 ml/kg) by esophageal tube, the other half were sham operated. Within each group, animals were treated for one, two or three weeks beginning with day 0. Dams and pups were sacrificed following a natural delivery. Iron (Fe), copper (Cu), zinc (Zn), and magnesium (Mg) were measured in maternal and fetal tissues by atomic absorption spectometry. The results indicated an increased fetal level of Zn, Mg and Fe in all groups treated with alcohol. Increased fetal levels of Cu were found in the group treated for three weeks with alcohol. No differences were found in maternal tissue levels. These changes in fetal levels correspond to the effect of alcohol on gestation. Alcohol-treated litters were anywhere from 2 to 6 days overdue, providing a longer time period in utero for nutrient uptake.
This work was done in partial fulfillment of the requirements of the Doctor of Science degree at the Harvard School of Public Health and supported in part by a grant-in-aid from the National Institutes of Health (AA-03289) and the Fund for Research and Teaching, Department of Nutrition, Harvard School of Public Health.
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Mendelson, R.A., Huber, A.M. (1980). The Effect of Duration of Alcohol Administration on the Deposition of Trace Elements in the Fetal Rat. In: Thurman, R.G. (eds) Alcohol and Aldehyde Metabolizing Systems-IV. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1419-7_31
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