Abstract
Equilibration of ethanol between dorsal subcutaneous air and blood is rapid, a steady state being already present in 60 seconds after air injection in the rat. The mean in vivo partition coefficient (blood/air) is 2,875, the linear regression coefficient having a standard error of 112, the high F value of this regression indicating the linearity and reliability of the estimates of calculated blood ethanol; the variance arises mainly from temperature variance of the air bleb. Although the concentration of alcohol in the blood must remain the standard of comparison, the production of the air bleb and its subsequent serial sampling is a virtually noninvasive technique which yields an almost immediate result at a sensitivity and specificity greater than that from the usual enzymatic determination of ethanol in blood.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Berton, A., 1959, Piles galvaniques sensibles a des traces de substances gazeuses liquides ou solides, Chim. anal., 41: 351.
Harger, R.N., E.G. Bridwell, and B.B. Raney, 1950, An aerometric method for the rapid determination of alcohol in water and body fluids, J. Biol. Chem., 128: 38.
Harger, R.N., B.B. Raney, E.G. Bridwell, and M.F. Kitchel, 1950, The partition ratio of alcohol between air and water, urine and blood; estimation and identification of alcohol in these liquids from analysis of air equilibrated with them, J. Biol. Chem., 183: 197.
Lester, D., 1962, Rapid methods for processing large numbers of tissue samples for ethyl alcohol, in: “Alcohol and Road Traffic”, Proc. Third Intl. Conf., Brit. Med. Assoc., London.
Lundquist, F., and H. Wolthers, 1958, The kinetics of alcohol elimination in man, Acta Pharm. Tox., Kbh, 14: 265.
Riley, E.P., E.X. Freed, and D. Lester, 1976, Selective breeding of rats for differences in reactivity to alcohol. An approach to an animal model of alcoholism. I. General procedures. J. Stud. Alc., 37: 1535.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer Science+Business Media New York
About this chapter
Cite this chapter
Lester, D., Lin, G.WJ. (1980). Distribution of Ethanol between Blood and Dorsal Subcutaneous Air of the Rat and the Feasibility of Using this Distribution Coefficient to Estimate Blood Ethanol. In: Thurman, R.G. (eds) Alcohol and Aldehyde Metabolizing Systems-IV. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1419-7_28
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1419-7_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1421-0
Online ISBN: 978-1-4757-1419-7
eBook Packages: Springer Book Archive