Protective Activity of Thymosin α1 Against Tumor Progression in Immunosuppressed Mice
Thymus gland has been shown to play an important role in the development, growth and function of lymphoid systems through a hormonal mechanism. One of the thymic hormones, thymosin (1), stimulates T cell development and corrects some immunodeficiency diseases resulting from lack of thymus functions. Considering the importance of T cells in immunoregulatory systems, thymosin is expected to be useful as a pharmaceutical agent for a variety of diseases which are caused by or which accompany the aberration of these systems.
KeywordsNatural Killer Natural Killer Cell Normal Mouse Spleen Cell Pulmonary Metastasis
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- 3.Goldstein, A. L., T. L. K. Low, M. McAdoo, J. McClure, G. B. Thurman, J. Rossio, C-Y. Lai, D. Chang, S-S. Wang, C. Harvey, A. H. Ramel, and J. Meienhofer. 1977. Thymosin al: Isolation and sequence analysis of an immunologically active thymic polypeptide. Proc. Natl. Acad. Sci. U.S.A. 74: 725.PubMedCrossRefGoogle Scholar
- 4.Fidler, I. J. 1970. Metastasis: Quantitative analysis of distribution and fate of tumor emboli labeled with 125I-5-iodo-2’-deoxyuridine. J. Natl. Cancer Inst. 45: 775.Google Scholar
- 7.Umeda, Y., J. Nakamura, H. Ishitsuka, and Y. Yagi. Protective activity of thymosin al against tumor progression in immunosuppressed mice through affecting NK cells (in preparation).Google Scholar
- 9.Ishitsuka, H., Y. Umeda, J. Nakamura and Y. Yagi. Protective activity of thymosin al against opportunistic infection in immunosuppressed mice (submitted).Google Scholar
- 10.Chirigos, M. A. 1978. In vitro and in vivo studies with thymosin, p. 305. In M. A. Chirigos (ed.), Immune modulation and control of neoplasia by adjuvant therapy. Raven Press, New York.Google Scholar