Abstract
Thymus gland has been shown to play an important role in the development, growth and function of lymphoid systems through a hormonal mechanism. One of the thymic hormones, thymosin (1), stimulates T cell development and corrects some immunodeficiency diseases resulting from lack of thymus functions. Considering the importance of T cells in immunoregulatory systems, thymosin is expected to be useful as a pharmaceutical agent for a variety of diseases which are caused by or which accompany the aberration of these systems.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hooper, J. A., M. C. McDaniel, G. B. Thurman, G. H. Cohen, R. S. Schulof, and A. L. Goldstein. 1975. Purification and properties of bovine thymosin. Ann. N. Y. Acad. Sci. 249: 125.
Wara, D. W., A. L. Goldstein, W. Doyle, and A. J. Ammann. 1975. Thymosin activity in patients with cellular immunodeficiency. New Engl. J. Med. 292: 70.
Goldstein, A. L., T. L. K. Low, M. McAdoo, J. McClure, G. B. Thurman, J. Rossio, C-Y. Lai, D. Chang, S-S. Wang, C. Harvey, A. H. Ramel, and J. Meienhofer. 1977. Thymosin al: Isolation and sequence analysis of an immunologically active thymic polypeptide. Proc. Natl. Acad. Sci. U.S.A. 74: 725.
Fidler, I. J. 1970. Metastasis: Quantitative analysis of distribution and fate of tumor emboli labeled with 125I-5-iodo-2’-deoxyuridine. J. Natl. Cancer Inst. 45: 775.
Kasai, M., M. Iwamori, Y. Nagai, K. Okumura, and T. Tada. 1980. A glycolipid on the surface of mouse natural killer cells. Eur. J. Immunol. 10: 175.
Zatz, M. M., E. M. Lance. 1971. The distribution of 51Cr-labeled lymphocytes into antigen stimulated mice. J. Exp. Med. 134: 224.
Umeda, Y., J. Nakamura, H. Ishitsuka, and Y. Yagi. Protective activity of thymosin al against tumor progression in immunosuppressed mice through affecting NK cells (in preparation).
Hanna, N., and C. R. Burton. 1981. Definitive evidence that natural killer (NK) cells inhibit experimental tumor metastasis in vivo. J. Immunol. 127: 1754.
Ishitsuka, H., Y. Umeda, J. Nakamura and Y. Yagi. Protective activity of thymosin al against opportunistic infection in immunosuppressed mice (submitted).
Chirigos, M. A. 1978. In vitro and in vivo studies with thymosin, p. 305. In M. A. Chirigos (ed.), Immune modulation and control of neoplasia by adjuvant therapy. Raven Press, New York.
Lipson, S. D., P. B. Chretien, R. Makuch, D. E. Kenady, and M. H. Cohen. 1973. Thymosin immunotherapy in patients with small cell carcinoma of the lung: Correlation of in vitro studies with clinical course. Cancer 43: 863.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ishitsuka, H., Umeda, Y., Sakamoto, A., Yagi, Y. (1983). Protective Activity of Thymosin α1 Against Tumor Progression in Immunosuppressed Mice. In: Klein, T., Specter, S., Friedman, H., Szentivanyi, A. (eds) Biological Response Modifiers in Human Oncology and Immunology. Advances in Experimental Medicine and Biology, vol 166. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1410-4_9
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1410-4_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1412-8
Online ISBN: 978-1-4757-1410-4
eBook Packages: Springer Book Archive