A Longitudinal Study of a Patient with Acquired Immunodeficiency Syndrome Using T Cell Subset Analysis
The Centers for Disease Control in 1981 reported an epidemic of Pneumocystis carinii pneumonia and Kaposi’s sarcoma in young previously healthy homosexual men (1,2). Additional reports have been published identifying viral, bacterial, fungal, and protozoan infections in this and other patient groups (3–5). Clinical observations and immunologic evaluations have defined an Acquired Immunologic Deficiency Syndrome (AIDS) in these patients (3–7).
KeywordsCell Subset Acquire Immunodeficiency Syndrome Peripheral Lymphocyte Mixed Lymphocyte Culture Small Bowel Biopsy
Unable to display preview. Download preview PDF.
- 1.Centers for Disease Control. 1981. Pneumocystis pneumonia-Los Angeles. Morbid. Mortal. Weekly. 30: 250.Google Scholar
- 2.Centers for Disease Control. 1981. Kaposi’s sarcoma and Pneumocystis pneumonia among homosexual men-New York City and California. Morbid. Mortal. Weekly. 30: 305.Google Scholar
- 3.Gottlieb, M. S., R. Schroff, H. M. Schanker, J. D. Weismann, P. T. Fan, R. A. Wolf, and A. Saxon. 1981. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N. Engl. J. Med. 305: 1425.Google Scholar
- 4.Masur, H., M. A. Michelis, J. B. Greene, I. Onorato, R. A. V. Stouwe, R. S. Holzman, G. Wormser, L. Brettman, M. Lange, H. W. Murray and S. Cunningham-Rundles. 1981. An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. N. Engl. J. Med. 305: 1431.Google Scholar
- 5.Siegal, F. P., C. Lopez, G. S. Hammer, A. E. Brown, S. J. Kornfeld, J. Gold, J. Hassett, S. Z. Hirschman, C. CunninghamRundles, B. R. Adelsberg, D. M. Parham, M. Siegal, S. CunninghamRundles and D. Armstrong. 1981. Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N. Engl. J. Med. 305: 1439.Google Scholar
- 6.Dent, P. B. 1972. Immunodepression by oncogenic viruses. Prog. Med. Virol. 14: 1.Google Scholar
- 7.Woodruff, J. F. and J. J. Woodruff. 1975. The effect of viral infections on the function of the immune system. In A. L. Notkins (ed.) Viral immunology and immunopathology. Academic Press, New York.Google Scholar
- 8.Centers for Disease Control Task Force on Kaposi’s Sarcoma and Opportunistic Infections. 1982. Epidemiologic aspects of the current outbreak of Kaposi’s sarcoma and opportunistic infections. N. Engl. J. Med. 306: 248.Google Scholar
- 9.Siegel, R. L., T. Issekutz, J. Schwaber, F. S. Rosen and R. S. Geha. 1981. The cellular defect in transient hypogammaglobulinemia of infancy. N. Engl. J. Med. 305: 1307.Google Scholar