A Feasibility Study to Determine if Microbicidal Activity can be Measured in Dexamethasone-Treated Macrophage Cultures

  • Robert J. Grasso
  • Robert C. GuayJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 166)


Macrophages play a major role in host resistance by ingesting and killing microorganisms. If these normal phagocytic processes are impaired by chemotherapeutic agents, host resistance decreases and susceptibility to infectious diseases increases accordingly. This may be the case with the glucocorticoid steroids since these agents suppress other macrophage functions (1,6,7). However, whether glucocorticoids act directly on macrophages in vivo to reduce host resistance by inhibiting their normal phagocytic functions remains to be established.


Macrophage Culture Murine Peritoneal Macrophage Phagocytosis Assay Viable Yeast Intracellular Killing 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Robert J. Grasso
    • 1
  • Robert C. GuayJr.
    • 1
  1. 1.Department of Medical Microbiology and ImmunologyUniversity of South Florida College of MedicineTampaUSA

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