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Cortical Slow Potentials, Depolarization of Glial Cells, and Extracellular Potassium Concentration

  • Alexander I. Roitbak
Part of the Brain Dynamics book series (BD)

Abstract

It is known that in response to a stimulus applied to the surface of the cortex after dendritic potential-20 to 30 msec negative potential reflecting EPSPs of apical dendrites—slow negativity (SN) arises (Chang, 1951). SN has been investigated in detail (Goldring and O’Leary, 1960; Roitbak, 1963, 1965; Roitbak et al., 1974). SN arises at a greater intensity of stimulation than dendritic potential; its amplitude increases with increases in the intensity of the stimulus; it can be recorded at a distance of 3 mm; and latency of SN is about 15 msec. SN increases during 50–80 msec, reaches 2 mV or more, and lasts 300–3000 msec. At the stimulation frequency 5–100 Hz SN summates and a negative shift of potential (NSP) occurs. SN is recorded in a volume of the cortex having the shape of a spherical segment. If double stimuli are used with deep anesthesia, the response to the second stimulus remains attenuated for up to 1 min. Based on the evidence obtained in a number of laboratories (Ransom et al., 1977; Roitbak et al., 1984, 1987; Somjen and Trachtenberg, 1979) it has been established beyond any doubt that K+ and glial cells contribute to the genesis of prolonged negative potentials at the cortical surface. However, some interesting points still remain to be clarified.

Keywords

Glial Cell Cortical Surface Contingent Negative Variation Extracellular Potassium Cortical Slow Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1993

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  • Alexander I. Roitbak

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