Abstract
Cortical spreading depression (CSD) and complete cerebral ischemia (CCI) are accompanied by a similar negative deflection of the DC signal of about 20 mV (Caspers et al., 1987; Hansen, 1985). Both events have been found to be analogous (Hansen, 1985) on the basis of similar ionic changes occurring concomitantly with the DC shift.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Benveniste H, Drejer J, Schousboe A, Diemer NH (1984): Elevation of the extra-cellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43: 1369–1374
Caspers H, Speckmann E-J, Lehmenkühler A (1987): DC potentials of the cerebral cortex: Seizure activities and changes in gas pressures. Rev Physiol Biochem Pharmacol 106: 127–178
Clark RM, Collins GGS (1976): The release of endogenous amino acids from the rat visual cortex. J Physiol 262: 383–400
Hansen M (1985): Effect of anoxia on ion distribution in the brain. Physiol Rev 65 (1): 101–148
Hansen AJ, Lauritzen M, Wieloch T (1988): NMDA antagonists inhibit cortical spreading depression, but not anoxic depolarization. In: Frontiers in Excitatory Amino Acid Research, Cavalheiro E, Lehmann J, Turski L, eds. New York: Alan Liss
Katyama Y, Becker DP, Tamura T, Martin NA, Cheung MK, Tsubokawa T (1989): Inhibition of massive ionic fluxes during cerebral ischemia (terminal depolarization) with an excitatory amino acid antagonist. J Cereb Blood Flow Metab 9 (Suppl 1): S57
Marrannes R, De Prins E, Fransen J, Wauquier A (1989): Comparison of the influence of calcium antagonists and NMDA antagonists on the cortical extracellular changes in ion concentration and DC-potential during ischemia. Acta Physiol Scand Suppl 582: 13
Marrannes R, Willems R, De Prins E, Wauquier A (1988): Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat. Brain Res 457: 226–240
Scheller D, Dengler K, Heister U (1990): Do the excitatory amino acids aspartate and glutamate generate spreading depression in vivo? In: Pharmacology of Cerebral Ischemia (Proceedings of the Third International Symposium on Pharmacology of Cerebral Ischemia, Marburg, Germany, 1990), Krieglstein J, ed. Stuttgart: Wissenschaftliche Verlagsgesellschaft
Scheller D, Heister U, Dengler K, Tegtmeier F (1991): Extracellular changes of aspartate and glutamate during generation and during propagation of cortical spreading depressions in rats. In: Cerebral Blood Flow in Migraine, Tension-Type Headache and Cluster Headache, Olesen J, ed. New York: Raven Press
Scheller D, Kolb J (1990): The internal reference technique in microdialysis: A practical approach to monitoring dialysis efficiency and to calculating tissue concentrations from dialysis samples. J Neurosci Meth 40: 31–38
Siesjö BK, Bengtsson F (1989): Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycaemia, and spreading depression: A unifying hypothesis. J Cereb Blood Flow Metab 9: 127–140
Westerberg E, Kehr I, Ungerstedt U, Wieloch T (1988): The NMDA-antagonist MK-801 reduces extracellular amino acid levels during hypoglycemia and prevents striatal damage. Neurosci Res Comm 3 (3): 151–158
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Scheller, D., Tegtmeier, F., Heister, U., Peters, T. (1993). Extracellular Changes of Aspartate, Glutamate, and Taurine in Relation to DC Changes during Complete Cerebral Ischemia and Cortical Spreading Depression. In: Haschke, W., Speckmann, E.J., Roitbak, A.I. (eds) Slow Potential Changes in the Brain. Brain Dynamics. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4757-1379-4_13
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1379-4_13
Publisher Name: Birkhäuser, Boston, MA
Print ISBN: 978-1-4757-1381-7
Online ISBN: 978-1-4757-1379-4
eBook Packages: Springer Book Archive