Extracellular Changes of Aspartate, Glutamate, and Taurine in Relation to DC Changes during Complete Cerebral Ischemia and Cortical Spreading Depression

  • D. Scheller
  • F. Tegtmeier
  • U. Heister
  • T. Peters
Part of the Brain Dynamics book series (BD)


Cortical spreading depression (CSD) and complete cerebral ischemia (CCI) are accompanied by a similar negative deflection of the DC signal of about 20 mV (Caspers et al., 1987; Hansen, 1985). Both events have been found to be analogous (Hansen, 1985) on the basis of similar ionic changes occurring concomitantly with the DC shift.


Excitatory Amino Acid NMDA Antagonist Cortical Spreading Depression Cereb Blood Flow Kynurenic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Benveniste H, Drejer J, Schousboe A, Diemer NH (1984): Elevation of the extra-cellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43: 1369–1374CrossRefGoogle Scholar
  2. Caspers H, Speckmann E-J, Lehmenkühler A (1987): DC potentials of the cerebral cortex: Seizure activities and changes in gas pressures. Rev Physiol Biochem Pharmacol 106: 127–178CrossRefGoogle Scholar
  3. Clark RM, Collins GGS (1976): The release of endogenous amino acids from the rat visual cortex. J Physiol 262: 383–400Google Scholar
  4. Hansen M (1985): Effect of anoxia on ion distribution in the brain. Physiol Rev 65 (1): 101–148Google Scholar
  5. Hansen AJ, Lauritzen M, Wieloch T (1988): NMDA antagonists inhibit cortical spreading depression, but not anoxic depolarization. In: Frontiers in Excitatory Amino Acid Research, Cavalheiro E, Lehmann J, Turski L, eds. New York: Alan LissGoogle Scholar
  6. Katyama Y, Becker DP, Tamura T, Martin NA, Cheung MK, Tsubokawa T (1989): Inhibition of massive ionic fluxes during cerebral ischemia (terminal depolarization) with an excitatory amino acid antagonist. J Cereb Blood Flow Metab 9 (Suppl 1): S57Google Scholar
  7. Marrannes R, De Prins E, Fransen J, Wauquier A (1989): Comparison of the influence of calcium antagonists and NMDA antagonists on the cortical extracellular changes in ion concentration and DC-potential during ischemia. Acta Physiol Scand Suppl 582: 13Google Scholar
  8. Marrannes R, Willems R, De Prins E, Wauquier A (1988): Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat. Brain Res 457: 226–240CrossRefGoogle Scholar
  9. Scheller D, Dengler K, Heister U (1990): Do the excitatory amino acids aspartate and glutamate generate spreading depression in vivo? In: Pharmacology of Cerebral Ischemia (Proceedings of the Third International Symposium on Pharmacology of Cerebral Ischemia, Marburg, Germany, 1990), Krieglstein J, ed. Stuttgart: Wissenschaftliche VerlagsgesellschaftGoogle Scholar
  10. Scheller D, Heister U, Dengler K, Tegtmeier F (1991): Extracellular changes of aspartate and glutamate during generation and during propagation of cortical spreading depressions in rats. In: Cerebral Blood Flow in Migraine, Tension-Type Headache and Cluster Headache, Olesen J, ed. New York: Raven PressGoogle Scholar
  11. Scheller D, Kolb J (1990): The internal reference technique in microdialysis: A practical approach to monitoring dialysis efficiency and to calculating tissue concentrations from dialysis samples. J Neurosci Meth 40: 31–38CrossRefGoogle Scholar
  12. Siesjö BK, Bengtsson F (1989): Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycaemia, and spreading depression: A unifying hypothesis. J Cereb Blood Flow Metab 9: 127–140CrossRefGoogle Scholar
  13. Westerberg E, Kehr I, Ungerstedt U, Wieloch T (1988): The NMDA-antagonist MK-801 reduces extracellular amino acid levels during hypoglycemia and prevents striatal damage. Neurosci Res Comm 3 (3): 151–158Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • D. Scheller
  • F. Tegtmeier
  • U. Heister
  • T. Peters

There are no affiliations available

Personalised recommendations