Prolonged Unstable Depression: A Modified Manifestation of Spreading Depression in Rat Hippocampus

  • Oscar Herreras
  • George G. Somjen
Part of the Brain Dynamics book series (BD)


The study reported here is part of our continuing investigation of the effects of elevated interstitial potassium on the functioning of central nervous system (CNS) tissue. Much of our work in the past has been concerned with isolated preparations (Balestrino et al., 1986; Czéh et al., 1988; Kawasaki et al., 1988). This chapter discusses experiments intended to compare the effect of prolonged elevation of extracellular potassium on hippocampus in situ to our earlier observations with CNS tissue slices in vitro.


Potential Shift Spreading Depression Voltage Shift Central Nervous System Location Spreading Depression Wave 
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  1. Albe-Fessard D, Sanderson P, Condes-Lara M, Delandsheer R, Giuffrida R, Ces-aro P (1984): Utilisation de la dépression envahissante de Leäo pour l’étude de relations entre structures centrales. An Acad Bras Ciênc 56: 371–384Google Scholar
  2. Balestrino M, Aitken PG, Somjen GG (1986): The effects of moderate changes of extracellular K+ and Cat+ on synaptic function in the hippocampal slice. Brain Res 377: 229–239CrossRefGoogle Scholar
  3. Bure J, Bure§ova O, Kfivânek J (1974): The Mechanism and Applications of Ledo’s Spreading Depression of Electroencephalographic Activity. Prague: AcademiaGoogle Scholar
  4. Czéh G, Obih JC, Somjen GG (1988): The effect of changing extracellular potassium concentration on synaptic transmission in isolated spinal cords. Brain Res 446: 50–60CrossRefGoogle Scholar
  5. De Mello WC (1987): Modulation of junctional permeability. In: Cell to Cell Communication, De Mello WC, ed. New York: Plenum PressCrossRefGoogle Scholar
  6. Do Carmo RJ, Martins-Ferreira H (1984): Spreading depression of Leib probed with ion-selective microelectrodes in isolated chick retina. An Acad Bras Ciênc 56: 401–422Google Scholar
  7. Gorelova N, Kfivanek J, Bure3 J (1987): Functional and metabolic correlates of long series of cortical spreading depression waves in rats. Brain Res 404: 379381Google Scholar
  8. Hansen AJ, Olsen CE (1980): Brain extracellular space during spreading depression and ischemia. Acta Physiol Scand 108: 355–365CrossRefGoogle Scholar
  9. Herreras O, Jing J, Somjen GG (1990): Potassium-induced depolarization in hippocampus in situ and in vitro: Limits of delayed recovery. Soc Neurosci Abstr 16: 277Google Scholar
  10. Herreras O, Menendez N, Herranz AS, Solis JM, Martin del Rio R (1989): Synaptic transmission at the Schaffer-CA1 synapse is blocked by 6,7-Dinitro-quinoxaline-2,3-dione: An in vivo brain dialysis study in the rat. Neurosci Lett 99: 119–124CrossRefGoogle Scholar
  11. Herreras O, Solis JM, Herranz AS, Martin del Rio R, Lerma J (1988): Sensory modulation of hippocampal transmission: 2. Evidence for a cholinergic locus of inhibition in the Schaffer CA1 synapse. Brain Res 461: 303–313CrossRefGoogle Scholar
  12. Kawasaki K, Czéh G, Somjen GG (1988): Prolonged exposure to high potassium concentration results in irreversible loss of synaptic transmission in hippocampal tissue slices. Brain Res 457: 322–329CrossRefGoogle Scholar
  13. Kuznetsova GD, Tsikalov EN, Markov AG, Podolec A (1988): New properties of spreading depression wave. In: Collective Dynamics of Excitation and Structure Formation in Biological Tissues, Yakhno VG, ed. Gorki: Institute of Applied Physics of the Academy of Sciences of the USSR (in Russian)Google Scholar
  14. Leäo AAP, Martins-Ferreira H (1959): The negative voltage variations of spreading depression and circulatory arrest. In: XXI Intern Congr Physiol Sci Buenos Aires, Abstract of meetingGoogle Scholar
  15. Marshall WH (1959): Spreading cortical depression of Leâo. Physiol Rev 39:239— 279Google Scholar
  16. Martins-Ferreira H (1954): Variaçôes lentas de voltagem do cortex cerebral. Rio de Janeiro: Instituto de BiofisicaGoogle Scholar
  17. Mugnaini E (1986): Cell junctions of astrocytes, ependyma and related cells in the mammalian central nervous system, with emphasis on the hypothesis of a generalized functional syncytium of supporting cells. In: Astrocytes, Vol. 1, Fedoroff S, Vernadakis A, eds. Orlando: Academic PressGoogle Scholar
  18. Nedergaard M, Hansen AJ (1988): Spreading depression is not associated with neuronal injury in the normal brain. Brain Res 449: 395–398CrossRefGoogle Scholar
  19. Okada YC, Lauritzen M, Nicholson C (1988): Magnetic field associated with spreading depression: A model for the detection of migraine. Brain Res 442: 185–190CrossRefGoogle Scholar
  20. Roitbak AI, Bobrov AV (1975): Spreading depression resulting from cortical punctures. Acta Neurobiol Exp 35: 761–768Google Scholar
  21. Snow RW, Taylor CP, Dudek FE (1983): Electrophysiological and optical changes in slices of rat hippocampus during spreading depression. J Neurophysiol 50: 561–572Google Scholar
  22. Somjen GG (1981): The why and how of measuring the activity of ions in extracellular fluid of spinal cord and cerebral cortex. In: The Application of Ion-Selective Electrodes, Zeuthen T, ed. Amsterdam: ElsevierGoogle Scholar
  23. Somjen GG (1987): Functions of glial cells in the cerebral cortex. In: Cerebral Cortex, Vol. 6, Jones EG, Peters A, eds. New York: Plenum PressCrossRefGoogle Scholar
  24. Somjen GG, Aitken PG (1984): The ionic and metabolic responses associated with neuronal depression of Leâo’s type in cerebral cortex and in hippocampal formation. An Acad Bras Ciênc 56: 495–504Google Scholar

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© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Oscar Herreras
  • George G. Somjen

There are no affiliations available

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