Abstract
Phospholipids such as Phosphatidylcholines have the tendency to form molecular bilayers and to minimize their surface by forming vesicles. Such liposomes have been tested with regard to their suitability as drug carriers. The number of drugs which has been entrapped into liposomes up till now is considerable. The main groups of interest today are: cytostatics, antibiotics, biological response modifiers and hormones. With some of these preparations clinical studies are now being carried out. Examples are: liposomes containing Amphotericin B, or Adriamycin, or lipophilic derivatives of Muramyldipeptide, etc. Many publications have been written about the properties of liposome-entrapped drugs and the biological effects which can be achieved with them2,12. From today’s point of view it is clear that liposomes as a dosage form have significant biopharmaceutical advantages, but only in specific fields (e.g. parenteral depots, drug targeting via the reticuloendothelial system, RES, etc.)
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© 1990 Springer Science+Business Media New York
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Stricker, H. (1990). Phospholipid Liposomes as Drug Carriers: Preparation and Properties. In: Hanin, I., Pepeu, G. (eds) Phospholipids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1364-0_9
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DOI: https://doi.org/10.1007/978-1-4757-1364-0_9
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