Abstract
The ability of phospholipids which make up liposomal bilayers to retain entrapped drug in the aqueous spaces might be altered by their phase transition temperature (Tc), since it is well known that drug leakage is markedly reduced if liposomes are kept at a storage temperature below the Tc of these phospholipids.
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References
Szoka, F., and Papahadjopoulos, D. (1980): Comparative properties and methods of preparation of lipid vesicles (Liposomes). Ann. Rev. Bioeng. 9: 467–508.
Ter-Minassian-Saraga, L. and Madelmont, G. (1985): Differential scanning calorimetry studies of hydration forces with phospholipid multilamellar systems. J. Coll. Interf. Sc. 85: 375–388.
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© 1990 Springer Science+Business Media New York
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Moufti, A., Genin, I., Madelmont, G., Deyme, M., Schneider, M., Puisieux, F. (1990). Relationship between Iodine Value and Phase Transition Temperature in Natural Hydrogenated Phospholipids. In: Hanin, I., Pepeu, G. (eds) Phospholipids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1364-0_26
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DOI: https://doi.org/10.1007/978-1-4757-1364-0_26
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