Introduction and Summary
It is known that the existence of lecithin is essential for intestinal fat absorption1 8 9 11 12 13. Oil and fat, both dietary and biliary phospholipids (PLs), are partially hydrolyzed by lipases and phospholipase A-2 (PLA2) in the small intestine, and are changed into fatty acids (FAs), monoglycerides (MGs) and lysophospholipids (LPs). These deacylated lipids are solubilized into mixed bile salt micelles2 6 14. Because of the ubiquitous existence of PLA2, in all cells3, the mixed solution of LPs and FAs may be very common. We examined the surface activity, in paticular, immersional and adhesional wettability, shown by an aqueous solution of soy lysophospholipid (SLP)/MG/FA, SLP/FA and SLP/MG, in vitro, and found that many lipid mixtures (compositions) showed significant surface activity when their MG and FA components consisted of unsaturated FA(ULFA) and/or medium chain FA(MCFA). A lipid mixture SLP/ medium chain MG (MCMG)/MCFA showed the highest surface activity. Wettability decreased rapidly when the moiety of saturated long chain FA in lipid mixtures increased. The higher ratio of MG and FA to SLP gave higher activity, and the addition of a solubilizer, such as bile salt, was necessary to dissolve them in water. The result of this study suggests that the surface activity of these mixed micelles affects intestinal digestion and absorption, and subsequently alters the level of the physiological phenomena which take place at the cell membrane.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Beil, F. U., and Grundy, J., (1980) Studies on plasma lipoproteins during absorption of exogenous lecithin in man, J. lipid Res. 21: 525–536.
Carey, M. C., Small, D. M., and Bliss, C. M., (1983) Lipid digestion and absorption, Ann. Rev. Physiol. 45: 651–677.
de Haas, G.H., de Gier, J., van den Bosch, H., and Wirtz, K. W. A., (1986), Twenty-five years of lipid and membrane biochemistry in Utrecht, in “Lipids and Membranes: Past, Present and Future” Op den Kamp, J. A. F., et. al. eds., pp. 1–44, Elsevier, Amsterdam.
Harkims, W. D., and Anderson, T. F., (1937) A simple accurate film balance of the vertical type for biological and chemical work, Am. Chem. Soc. 59: 2189–2197.
Linthorst, H. W., Bennett-Clark, S., and Holt, P. R., (1977) Triglycéride emulsification by amphipaths present in the intestinal lumen during digestion of fat, J. Colloid Interface Sci. 60: 1–10.
Mead, J. F., Alfin-Slater, R. B., Howton, D. R., and Popjak, G., (1986), Digestion and absorption of Lipids, in “ Lipids, Chemistry, Biochemistry and Nutrition”, pp. 255–272, Plenum Press, New York.
Nakai, E., Suzuki, K., Satoh, S., and Katoh, M., (1989), Method of deacylation of phospholipid by phospholipase A-2, Japan Pat. laid open 89/16595.
O’Doherty P. J. A., Kakis, G., and Kuksis, A., (1973) Role of luminal lecithin in intestinal fat absorption, Lipids 8: 249–255.
Rampone, A. J., and Lawrence, R. L., (1977) The effect of phosphatidylcholine and lysophosphatidylcholine on the absorption and mucosal metabolism of oleic acid and cholesterol in vitro, Biochim. Biophys. Acta 486: 500–510.
Seyferth, H., and Morgan, O. M., (1938) The canvas disk wetting test, Am. Dyestuff Reptr. 27: 525–532.
Tso, P., Balint, J. A., and Simmonds, W. J., (1977) Role of biliary lecithin in lymphatic transport of fat, Gastroenterology 73: 1362–1367.
Tso, P., Lam, J., and Simmonds, W. J., (1978) The importace of the lysophosphatidylcholine and choline moity of bile phosphatidylcholine in lymphatic transport of fat, Biochim. Biophys. Acta 528: 364–372.
Tso, P., Kendric, H., Balint, J. A., and Simmonds, W. J., (1981) Role of biliary phosphatidylcholine in the absorption and transport dietary triolein in the rat, Gastroenterology 80: 60–65.
Yih-Fu Shian, (1987), Lipid digestion and absorption, in “Physiology of Gastrointestinal Tract” 2nd ed., Johnson, L. R., et al. eds., vol. 2, pp 1527–1556, Raven Press, New York.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer Science+Business Media New York
About this chapter
Cite this chapter
Fujita, S., Suzuki, K. (1990). Significant Surface Activity Shown by the Mixture of Partially Deacylated Lipids. In: Hanin, I., Pepeu, G. (eds) Phospholipids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1364-0_23
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1364-0_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1366-4
Online ISBN: 978-1-4757-1364-0
eBook Packages: Springer Book Archive