Phospholipids pp 233-240 | Cite as

Phosphatidylinositol Derivatives as Cell Signalling Molecules

  • John N. Hawthorne


Interest in phosphatidylinositol metabolism began with the observations of Hokin and Hokin (19) which linked turnover of this lipid with the activation of receptors. Folch (14) had shown that brain contained a more complex phosphoinositide and this product proved later to be a mixture of three such lipids, phosphatidylinositol itself (PtdIns), phosphatidylinositol 4-phosphate (PtdIns 4P) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Dawson (9) showed that 32P was rapidly incorporated into brain PtdIns 4P and PtdIns(4,5)P2, suggesting that these so-called polyphosphoinositides might also have an important function.


Sciatic Nerve Aldose Reductase Inositol Phosphate Bovine Chromaffin Cell Cell Signalling Molecule 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • John N. Hawthorne
    • 1
  1. 1.Department of BiochemistryNottingham University Medical School Queen’s Medical CentreNottinghamUK

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