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Phospholipids pp 133–165Cite as

Therapeutic Aspects of Liposomes

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Abstract

The fate of a drug after administration in vivo is determined by a combination of several processes: distribution and elimination when given intravenously and absorption, distribution and elimination when an extravascular route is used. Regardless of the mechanisms involved, each of these processes depends mainly on the physico-chemical properties of the drug and therefore, for the most part, on its chemical structure.

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Abbreviations

ADM:

adriamycin

AMB:

amphotericin B

Ara-C:

cytosine arabinoside

ATP:

adenosine triphosphate

Chol:

cholesterol

DCP:

dicetylphosphate

DMPC:

dimyristoylphosphatidylcholine

DMPG:

dimyristoylphosphatidylglycerol

DOPC:

dioleoylphosphatidylcholine

DOPE:

dioleoylphosphatidylethanolamine

DPPC:

dipalmitoylphosphatidylcholine

DTPA:

diethylene triamine pentaacetic acid

MDP:

muramyldipeptide

MLV:

multilamellar vesicles

MTP-PE:

muramyltripeptide-phosphatidylethanolamine

OA:

oleic acid

PC:

phosphatidylcholine

PS:

phosphatidylserine

rIFN:

recombinant human interferon

RES:

reticuloendothelial system

REV:

reverse phase vesicles

SA:

stearylamine

SOPE:

DN-succinyldioleoylphosphatidylethanolamine

SUV:

small unilamellar vesicles

Tc :

phase transition temperature

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Authors and Affiliations

  1. Laboratoire de Pharmacie Galénique et de Biopharmacie, URA CNRS 1218, Université de Paris XI, Châteany-Malabry Cédex, France

    F. Puisieux, G. Barratt, L. Roblot-Treupel, J. Delattre, P. Couvreur & J. Ph. Devissaguet

  2. Laboratoire de Biochimie, Université de Paris V, Paris, France

    J. Delattre

Authors
  1. F. Puisieux
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  2. G. Barratt
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  3. L. Roblot-Treupel
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  4. J. Delattre
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  5. P. Couvreur
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  6. J. Ph. Devissaguet
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Editor information

Editors and Affiliations

  1. Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois, USA

    Israel Hanin

  2. University of Florence, Florence, Italy

    Giancarlo Pepeu

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Puisieux, F., Barratt, G., Roblot-Treupel, L., Delattre, J., Couvreur, P., Devissaguet, J.P. (1990). Therapeutic Aspects of Liposomes. In: Hanin, I., Pepeu, G. (eds) Phospholipids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1364-0_11

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  • DOI: https://doi.org/10.1007/978-1-4757-1364-0_11

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