Many drugs in therapeutic, diagnostic and preventive medicine would be more effective if they were to act selectively, where they are needed (4). Barring a few exceptions (e.g. antibiotics interfering with metabolic pathways in bacteria), however, drug selectivity is often poor. For example, in cancer chemotherapy cytostatic agents also damage normal rapidly proliferating cells. Additional obstacles to effective drug action include inaccessibility of targets (e.g. many antimicrobial agents are unable to reach microbe-infested intracellular sites), drug instability in the biological milieu, premature drug loss through excretion and allergic reactions to some drugs.
KeywordsTetanus Toxoid Lysosomal Storage Disease Positive Surface Charge Muramyl Dipeptide Liposomal Drug
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