Voltage Gating in VDAC

Toward a Molecular Mechanism
  • Marco Colombini


The reconstitution of transport systems into phospholipid bilayer membranes was originally undertaken in order to gain new insights into the structure and mechanism of action of these molecular machines. This goal is being achieved as evidenced by the contents of this book. This chapter deals with some of the results obtained from studies performed on a reconstituted channel-forming protein isolated from mitochondria. It focuses on the results that yield information on the molecular mechanism that causes this channel to be voltage-gated.


Outer Membrane Voltage Gating Pore Radius Closed State Voltage Dependence 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Marco Colombini
    • 1
  1. 1.Laboratories of Cell Biology, Department of ZoologyUniversity of MarylandCollege ParkUSA

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