Phosphorylation of a Reconstituted Potassium Channel
Ion channels in biological membranes are dynamic entities. They of course act as pores through which ions can move down their electrochemical gradients, but more than that, many of them are regulatable pores. Channels can exist in more than one functional state, and rapid transitions between these states can be regulated by the voltage across the membrane or by the binding of a small molecule to a specific receptor that is intimately associated with the channel. Furthermore, it is now becoming evident that these rapid transitions are themselves subject to longer-term modulation, which may last for seconds, minutes, or even hours.
KeywordsCatalytic Subunit Membrane Patch Patch Electrode Molluscan Neuron Trans Side
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