Characterization of Dihydropyridine-Sensitive Calcium Channels from Purified Skeletal Muscle Transverse Tubules

  • Roberto Coronado
  • Hubert Affolter


The activity of calcium channels contributes to a large number of cellular functions, of which the best known are neurotransmitter release, pacemaking, motility, and muscle contraction (Reuter, 1983; Hille, 1984). Yet many more roles may be envisioned, as suggested by the fact that almost all cells, procaryotes and eucaryotes, have well-defined calcium currents (see Hille, 1984). More than any other channel, the calcium channel is presently the target of vigorous chemical and clinical research aming to understand how antiarrhythmic and antihypertensive drugs, such as dihydropyridines, modulate, block, or antagonize calciumchannel function (Janis et al., 1985).


Calcium Channel Calcium Current Open Event Rabbit Skeletal Muscle Holding Potential 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Roberto Coronado
    • 1
  • Hubert Affolter
    • 1
  1. 1.Department of PharmacologyUniversity of North Carolina at Chapel HillChapel HillUSA

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