The Sarcoplasmic Reticulum Potassium Channel

Lipid Effects
  • Joan Bell


The conduction, gating, and pharmacological properties of the sarcoplasmic reticulum (SR) K+ channel have been well characterized (Coronado et al., 1980; Coronado and Miller, 1980; Labarca et al., 1980; Miller, 1982). It is a relatively “simple” channel in that it exists in only two states, open or closed, with quite slow (seconds) transitions between the two, is gated by voltage only, and does not inactivate. It thus provides an excellent vehicle for studying possible lipid effects on a channel protein. In turn, the artificial bilayer system is the ideal means for studying lipid effects because both the membrane composition and the ionic milieu can be determined and manipulated by the experimenter. The topic of this chapter is the role of the electrical charge of the bilayer in the observed conduction characteristics of the SR K+ channel in artificial bilayers.


Charge Density Sarcoplasmic Reticulum Surface Potential Lipid Monolayer Channel Mouth 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Joan Bell
    • 1
  1. 1.Department of Physiology and Biophysics, Laboratory of Human Reproduction and Reproductive BiologyHarvard Medical SchoolBostonUSA

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