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Skeletal Muscle Sodium Channels

Isolation and Reconstitution

  • Chapter
Ion Channel Reconstitution

Abstract

In mammalian muscle, a voltage-sensitive sodium channel controls the transient increase in membrane conductance that produces an action potential in the sarcolemma and T-tubular membranes. The time- and voltage-dependent characteristics of the currents regulated by this channel have been studied extensively over the past few decades, first using the traditional approach of voltage clamp (Adrian et al., 1970) and more recently at the single-channel level using patch-clamp technology (Sigworth and Neher, 1980).

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Authors and Affiliations

  1. David Mahoney Institute of Neurological Sciences and Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    J. C. Tanaka, R. E. Furman & R. L. Barchi

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  1. J. C. Tanaka
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  2. R. E. Furman
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  3. R. L. Barchi
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Editors and Affiliations

  1. Brandeis University, Waltham, Massachusetts, USA

    Christopher Miller

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Tanaka, J.C., Furman, R.E., Barchi, R.L. (1986). Skeletal Muscle Sodium Channels. In: Miller, C. (eds) Ion Channel Reconstitution. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1361-9_11

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  • DOI: https://doi.org/10.1007/978-1-4757-1361-9_11

  • Publisher Name: Springer, Boston, MA

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