The Physical Nature of Planar Bilayer Membranes

  • Stephen H. White

Abstract

A major part of the general strategy for defining the structure-function relationships of ion channels is to reconstitute isolated channel proteins into planar lipid bilayer membranes separating two aqueous compartments. In principle, this part of the strategy allows one to manipulate the lipid and aqueous environments of the protein to elucidate their roles in channel assembly and function in vivo. Its success depends on how well one can use the natural physicochemical behavior of the bilayer system to control the reconstitution process and the composition and properties of the lipid bilayer itself. Consequently, the serious student of reconstitution must come to terms with the physical chemistry of these bilayers variously referred to as planar lipid bilayers, black lipid membranes, or thin lipid films.

Keywords

Contact Angle Bilayer Membrane Lipid Bilayer Membrane Phase Rule Planar Bilayer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Stephen H. White
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of California at IrvineIrvineUSA

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