Abstract
Epithelial lesions of the mouth have been reported to respond to treatment with either riboflavin or pyridoxine. Earlier we had hypothesized that these lesions may be due to cellular deficiency of pyridoxal phosphate (PLP), since the enzyme pyridoxaminephosphate oxidase (PPO) is a flavo protein. Subsequent studies showed that PPO activity is markedly reduced in tissues of riboflavin deficient rat and man1. The in vivo conversion of parenterally administered pyridoxine to PLP was also markedly impaired in riboflavin deficient humans2. Despite this, the concentration of PLP in tissues of riboflavin deficient rat and blood of deficient humans was normal1.
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References
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© 1980 Springer Science+Business Media New York
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Bamji, M.S. (1980). Metabolism of Pyridoxine in Riboflavin Deficiency. In: Santos, W., Lopes, N., Barbosa, J.J., Chaves, D., Valente, J.C. (eds) Nutritional Biochemistry and Pathology. Nutrition and Food Science, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1349-7_12
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DOI: https://doi.org/10.1007/978-1-4757-1349-7_12
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